Health Challenges of the Pacific Region: Insights From History, Geography, Social Determinants, Genetics, and the Microbiome
| Autor: | Paul F. Horwood, Arnaud Tarantola, Cyrille Goarant, Mariko Matsui, Elise Klement, Masahiro Umezaki, Severine Navarro, Andrew R. Greenhill |
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| Přispěvatelé: | College of Public Health, Medical and Veterinary Sciences [Townsville, QLD, Australia], James Cook University (JCU), Institut Pasteur de Nouvelle-Calédonie, Réseau International des Instituts Pasteur (RIIP), Internal Medicine and Infectious Diseases Department [Noumea, New Caledonia], Centre hospitalier territorial Gaston-Bourret [Nouméa], Department of Human Ecology [Tokyo, Japan] (Graduate School of Medicine), Graduate School of Medicine and Faculty of Medicine Kyoto University, Immunology Department [Herston, QLD, Australia], QIMR Berghofer Medical Research Institute, School of Health and Life Sciences [Churchill, VIC, Australia], Federation University Australia, SN is supported by a fellowship from the Woolworth Centre for Childhood Nutrition Research and the Children’s Hospital Foundation #50197 and #WIS0092018. EK is supported by the Government of New Caledonia., Goarant, Cyrille |
| Rok vydání: | 2019 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
0301 basic medicine Social Determinants of Health Double burden infectious disease Oceania Immunology microbiome Review Communicable Diseases Indigenous 03 medical and health sciences 0302 clinical medicine [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases medicine Health Services Indigenous Humans Immunology and Allergy genetics Melanesians Microbiome Social determinants of health Indigenous Peoples Noncommunicable Diseases non-communicable disease Disease burden 2. Zero hunger Genetics Geography Microbiota 1. No poverty Non-communicable disease medicine.disease Pacific 3. Good health nutrition 030104 developmental biology Infectious disease (medical specialty) [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases Public Health lcsh:RC581-607 030215 immunology |
| Zdroj: | Frontiers in Immunology Frontiers in Immunology, Frontiers, 2019, 10, pp.2184. ⟨10.3389/fimmu.2019.02184⟩ Frontiers in Immunology, Vol 10 (2019) |
| ISSN: | 1664-3224 |
| Popis: | International audience; The Pacific region, also referred to as Oceania, is a geographically widespread region populated by people of diverse cultures and ethnicities. Indigenous people in the region (Melanesians, Polynesians, Micronesians, Papuans, and Indigenous Australians) are over-represented on national, regional, and global scales for the burden of infectious and non-communicable diseases. Although social and environmental factors such as poverty, education, and access to health-care are assumed to be major drivers of this disease burden, there is also developing evidence that genetic and microbiotic factors should also be considered. To date, studies investigating genetic and/or microbiotic links with vulnerabilities to infectious and non-communicable diseases have mostly focused on populations in Europe, Asia, and USA, with uncertain associations for other populations such as indigenous communities in Oceania. Recent developments in personalized medicine have shown that identifying ethnicity-linked genetic vulnerabilities can be important for medical management. Although our understanding of the impacts of the gut microbiome on health is still in the early stages, it is likely that equivalent vulnerabilities will also be identified through the interaction between gut microbiome composition and function with pathogens and the host immune system. As rapid economic, dietary, and cultural changes occur throughout Oceania it becomes increasingly important that further research is conducted within indigenous populations to address the double burden of high rates of infectious diseases and rapidly rising non-communicable diseases so that comprehensive development goals can be planned. In this article, we review the current knowledge on the impact of nutrition, genetics, and the gut microbiome on infectious diseases in indigenous people of the Pacific region. |
| Databáze: | OpenAIRE |
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