New Nordic Diet versus Average Danish Diet: A Randomized Controlled Trial Revealed Healthy Long-Term Effects of the New Nordic Diet by GC–MS Blood Plasma Metabolomics
| Autor: | Søren Balling Engelsen, Thomas Larsen, Gözde Gürdeniz, Evrim Acar, Francesco Savorani, Sanne Kellebjerg Poulsen, Bekzod Khakimov, Lars O. Dragsted, Arne Astrup |
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| Rok vydání: | 2016 |
| Předmět: |
Male
health benefit 0301 basic medicine Denmark Metabolite Physiology PLS-DA Biochemistry law.invention Plasma ASCA biomarker diet metabolomics PARAFAC2 weight loss Chemistry (all) chemistry.chemical_compound Randomized controlled trial law Weight loss Vegetables Blood plasma Longitudinal Studies Middle Aged Metabolome language Biomarker (medicine) Female Seasons medicine.symptom Adult medicine.medical_specialty Gas Chromatography-Mass Spectrometry Danish Young Adult 03 medical and health sciences Sex Factors Internal medicine medicine Animals Humans Obesity 030109 nutrition & dietetics business.industry Feeding Behavior General Chemistry language.human_language 030104 developmental biology Endocrinology Blood pressure Seafood chemistry Fruit Insulin Resistance Edible Grain business |
| Zdroj: | Journal of Proteome Research. 15:1939-1954 |
| ISSN: | 1535-3907 1535-3893 |
| DOI: | 10.1021/acs.jproteome.6b00109 |
| Popis: | A previous study has shown effects of the New Nordic Diet (NND) to stimulate weight loss and lower systolic and diastolic blood pressure in obese Danish women and men in a randomized, controlled dietary intervention study. This work demonstrates long-term metabolic effects of the NND as compared with an Average Danish Diet (ADD) in blood plasma and reveals associations between metabolic changes and health beneficial effects of the NND including weight loss. A total of 145 individuals completed the intervention and blood samples were taken along with clinical examinations before the intervention started (week 0) and after 12 and 26 weeks. The plasma metabolome was measured using GC-MS, and the final metabolite table contained 144 variables. Significant and novel metabolic effects of the diet, resulting weight loss, gender, and intervention study season were revealed using PLS-DA and ASCA. Several metabolites reflecting specific differences in the diets, especially intake of plant foods and seafood, and in energy metabolism related to ketone bodies and gluconeogenesis formed the predominant metabolite pattern discriminating the intervention groups. Among NND subjects, higher levels of vaccenic acid and 3-hydroxybutanoic acid were related to a higher weight loss, while higher concentrations of salicylic, lactic, and N-aspartic acids and 1,5-anhydro-d-sorbitol were related to a lower weight loss. Specific gender and seasonal differences were also observed. The study strongly indicates that healthy diets high in fish, vegetables, fruit, and whole grain facilitated weight loss and improved insulin sensitivity by increasing ketosis and gluconeogenesis in the fasting state. |
| Databáze: | OpenAIRE |
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