Effects of chronic alpha and beta adrenoceptor blockade with labetalol on plasma catecholamines and renal function in hypertension
| Autor: | R. de Châtel, Peter Weidmann, Gerald T. Keusch, François C. Reubi, Walter H. Ziegler |
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| Rok vydání: | 1980 |
| Předmět: |
Adult
Male medicine.medical_specialty Renal function Alpha (ethology) Kidney Essential hypertension Norepinephrine (medication) Catecholamines Internal medicine Drug Discovery medicine Humans Labetalol Genetics (clinical) Aged Chemistry Sodium General Medicine Middle Aged medicine.disease Epinephrine Endocrinology Ethanolamines Renal blood flow Hypertension Catecholamine Molecular Medicine Female Glomerular Filtration Rate medicine.drug |
| Zdroj: | Klinische Wochenschrift. 58:25-29 |
| ISSN: | 1432-1440 0023-2173 |
| DOI: | 10.1007/bf01477140 |
| Popis: | Plasma catecholamines and renal function were evaluated in 18 patients with essential hypertension treated with the alpha and beta adrenoceptor blocking agent, labetalol. Following 6 weeks of labetalol therapy, blood levels of epinephrine and norepinephrine remained unaltered. Glomerular filtration rate and renal plasma flow were decreased similarly by about 20% (P less than 0.025). Tubular rejection fraction of sodium was increased by 36% (P less than 0.001) while sodium excretion was comparable to control conditions. Labetalol's potential to cause a mild reduction in kidney function should be considered, but may have no clinical consequences in most hypertensive patients receiving such treatment. The lack of increased plasma catecholamine levels during therapy supports the concept that labetalol's alpha-blocking potential is limited to post-junctional receptors, leaving the prejunctional feedback control of catecholamine release intact. Moreover, labetalol's blood pressure-lowering mechanism may be largely independent of changes in sympathetic nervous activity. |
| Databáze: | OpenAIRE |
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