Infant birthweight and risk of childhood cancer: international population-based case control studies of 40 000 cases
| Autor: | Logan G. Spector, Beth A. Mueller, Michael F. Murphy, Julie Von Behren, Susan E. Puumala, Kathryn J. Bunch, Colleen McLaughlin, Susan E. Carozza, Eric J. Chow, Peggy Reynolds, Kate A. O'Neill, Tim J. Vincent |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Adolescent Epidemiology Birth weight Gestational Age Multiple Birth Offspring Risk Factors Neoplasms Odds Ratio medicine Birth Weight Humans Sex Distribution Risk factor Child business.industry Infant Newborn Case-control study Infant Cancer Gestational age General Medicine Odds ratio medicine.disease United Kingdom United States Birth order Socioeconomic Factors Case-Control Studies Child Preschool Etiology Female Birth Order business |
| Zdroj: | International Journal of Epidemiology. 44:153-168 |
| ISSN: | 1464-3685 0300-5771 |
| Popis: | Background High birthweight is an established risk factor for childhood leukaemia. Its association with other childhood cancers is less clear, with studies hampered by low case numbers. Methods We used two large independent datasets to explore risk associations between birthweight and all subtypes of childhood cancer. Data for 16 554 cases and 53 716 controls were obtained by linkage of birth to cancer registration records across five US states, and 23 772 cases and 33 206 controls were obtained from the UK National Registry of Childhood Tumours. US, but not UK, data were adjusted for gestational age, birth order, plurality, and maternal age and race/ethnicity. Results Risk associations were found between birthweight and several childhood cancers, with strikingly similar results between datasets. Total cancer risk increased linearly with each 0.5 kg increase in birthweight in both the US [odds ratio 1.06 (95% confidence interval 1.04, 1.08)] and UK [1.06 (1.05, 1.08)] datasets. Risk was strongest for leukaemia [USA: 1.10 (1.06, 1.13), UK: 1.07 (1.04, 1.10)], tumours of the central nervous system [USA: 1.05 (1.01, 1.08), UK: 1.07 (1.04, 1.10)], renal tumours [USA: 1.17 (1.10, 1.24), UK: 1.12 (1.06, 1.19)] and soft tissue sarcomas [USA: 1.12 (1.05, 1.20), UK: 1.07 (1.00, 1.13)]. In contrast, increasing birthweight decreased the risk of hepatic tumours [USA: 0.77 (0.69, 0.85), UK: 0.79 (0.71, 0.89) per 0.5 kg increase]. Associations were also observed between high birthweight and risk of neuroblastoma, lymphomas, germ cell tumours and malignant melanomas. For some cancer subtypes, risk associations with birthweight were non-linear. We observed no association between birthweight and risk of retinoblastoma or bone tumours. Conclusions Approximately half of all childhood cancers exhibit associations with birthweight. The apparent independence from other factors indicates the importance of intrauterine growth regulation in the aetiology of these diseases. |
| Databáze: | OpenAIRE |
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