Factors on prognosis in patients of stage pT3N0M0 thoracic esophageal squamous cell carcinoma after two-field esophagectomy
| Autor: | Lili Wang, Jifang Yao, Zhan Qi, Jing Li, Yuxiang Wang, Xueying Qiao, Ming He, Qiong Yang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Esophageal Neoplasms medicine.medical_treatment Adjuvant therapy survival lcsh:RC254-282 Lesion Risk Factors Medicine Humans Radiology Nuclear Medicine and imaging Esophagus Stage (cooking) Neoplasm Metastasis Lymph node Aged Neoplasm Staging Univariate analysis business.industry esophageal neoplasm/pT3N0M0 General Medicine Middle Aged Prognosis lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Combined Modality Therapy Survival Analysis Surgery Radiation therapy medicine.anatomical_structure Oncology Esophagectomy Carcinoma Squamous Cell esophagectomy Female Esophageal Squamous Cell Carcinoma medicine.symptom business Follow-Up Studies |
| Zdroj: | Journal of Cancer Research and Therapeutics, Vol 11, Iss 5, Pp 16-23 (2015) |
| ISSN: | 1998-4138 0973-1482 |
| Popis: | Aims: To evaluate prognosis and its related factors in patients of pT3N0M0 thoracic esophageal squamous cell carcinoma (ESCC). Subjects and Methods: From January 2008 to December 2009, 249 patients of stage T3N0M0 thoracic ESCC were treated with two-field esophagectomy. Among them, 171 males and 78 females; the median age was 60 years old (range 33-78 years). Site of lesion: 39 in upper-, 166 in middle-, and 44 patients in lower-thoracic esophagus; the median length of lesion was 5 cm (range 2-12 cm); the degree of adhesion during surgery: No adhesions in 35, mild adhesions in 90, and severe adhesions in 124 patients; the median number of dissected lymph node (LN) was 9 (range 1-27). Ninety-eight patients are treated with surgery alone, 151 patients with postoperative adjuvant treatment (20 with radiotherapy, 110 with chemotherapy, and 21 patients with radiotherapy and chemotherapy). Statistical analysis was performed using SPSS 13.0 statistical software. Results: Follow-up deadline was July 2013. The 1-, 3-, 5-year overall survival (OS) were 90.0%, 68.7% and 55.2%; Univariate analysis identified gender, location of lesion, differentiation of pathology and hemoglobin (Hb) levels were prognostic factors for OS (P < 0.05); multivariate analysis showed, location of lesion, Hb levels, mediastinal small LN ( |
| Databáze: | OpenAIRE |
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