Temporal dynamics of hepatitis C genotypes in a five-year hospital-based surveillance in Northern Italy
| Autor: | Maria Cristina Arcangeletti, Adriana Calderaro, Alessandra Fazzi, Carlo Chezzi, F. De Conto, F. Pinardi, F. Ferraglia, M.C. Medici |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Serum 0301 basic medicine medicine.medical_specialty Genotype Genotyping Techniques Hepatitis C virus Population Hepacivirus Biology medicine.disease_cause 03 medical and health sciences Sex Factors 0302 clinical medicine Medical microbiology Virology Epidemiology medicine Animals Humans Infection control education Aged Molecular Epidemiology education.field_of_study Age Factors General Medicine Hepatitis C Hepatitis C Chronic Middle Aged Viral Load medicine.disease Hospitals 030104 developmental biology Italy Epidemiological Monitoring Female 030211 gastroenterology & hepatology Viral load |
| Zdroj: | Archives of Virology. 161:2727-2737 |
| ISSN: | 1432-8798 0304-8608 |
| DOI: | 10.1007/s00705-016-2975-8 |
| Popis: | Hepatitis C virus (HCV) genotypes have became important epidemiological markers in the management of HCV-infected subjects and infection treatment. The dynamics of HCV genotypes are changing in Europe. During a five-year (2009-2013) hospital-based surveillance in the area of Parma, Northern Italy, serum/plasma samples from 1,265 HCV RNA-positive subjects were genotyped. Subtypes 1b, 3a, and 1a were predominant (32.6 %, 19.1 %, and 17.8 %, respectively), with a correlation between viral load and gender. Subtypes 1a and 3a were more frequent in adults and males with a significant difference with the over-50 age group and females (P > 0.0001). Subtype 1b, as well as 2a/2c and G2 not-subtypeable (15.7 % and 7.2 %, respectively), were more common in females and in the over-50 age group compared to males (P |
| Databáze: | OpenAIRE |
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