Insertion of poly(ethylene glycol) derivatized phospholipid into pre-formed liposomes results in prolonged in vivo circulation time
| Autor: | Zhu George Z, Mary S. Newman, Theresa M. Allen, Cecilia J. Mendez, Paul S. Uster, Barbra E. Daniel |
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| Rok vydání: | 1996 |
| Předmět: |
Male
Poly ethylene glycol Biophysics Phospholipid Critical micellar concentration Biochemistry Polyethylene Glycols Rats Sprague-Dawley chemistry.chemical_compound Structural Biology In vivo Genetics Animals Pharmacokinetics Solubility Insertion Molecular Biology Liposome Chromatography Dose-Response Relationship Drug Poly(ethylene glycol) Chemistry Phosphatidylethanolamines Cell Biology Rats Critical micelle concentration Liposomes Circulation time Conjugate |
| Zdroj: | FEBS Letters. 386:243-246 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/0014-5793(96)00452-8 |
| Popis: | Transfer of MPEG1900-DSPE from micellar phase to pre-formed liposomes imparts long in vivo circulation half-life to an otherwise rapidly cleared lipid composition. MPEG1900-DSPE transfers efficiently and quickly in a time and temperature dependent manner. There is negligible content leakage and a strong correlation between assayed mol% MPEG1900-DSPE, liposome diameter increase, and pharmacokinetic parameters such as distribution phase half-life. Since a biological attribute (liposome clearance rate) can be modified by the insertion process, it suggests a simple and economical way to impart site-specific targeting to a variety of liposome delivery systems. This method is also a convenient way to measure the ‘brush’ thickness of such conjugates directly. |
| Databáze: | OpenAIRE |
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