T-type calcium channels in neuropathic pain
| Autor: | Amaury François, Emmanuel Bourinet, Sophie Laffray |
|---|---|
| Přispěvatelé: | Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), UR MAEP, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), bourinet, emmanuel |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology [SDV]Life Sciences [q-bio] Allodynia Neuralgia/drug therapy/genetics/*metabolism 03 medical and health sciences Calcium Channels T-Type 0302 clinical medicine Calcium Channel Blockers/therapeutic use Fibromyalgia medicine Humans Animals [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Ion channel Low-threshold mechanoreceptors Membrane potential Voltage-dependent calcium channel business.industry T-type calcium channel [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology medicine.disease Calcium Channel Blockers 3. Good health Neuropathy [SDV] Life Sciences [q-bio] 030104 developmental biology Anesthesiology and Pain Medicine Neurology T-Type/genetics/*metabolism Neuropathic pain Neuralgia [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Neurology (clinical) Calcium Channels medicine.symptom business Neuroscience 030217 neurology & neurosurgery Cold |
| Zdroj: | PAIN PAIN, Elsevier, 2016, 157 Suppl 1, pp.S15--22. ⟨10.1097/j.pain.0000000000000469⟩ PAIN, 2016, 157 Suppl 1, pp.S15--22. ⟨10.1097/j.pain.0000000000000469⟩ |
| ISSN: | 0304-3959 1872-6623 |
| DOI: | 10.1097/j.pain.0000000000000469⟩ |
| Popis: | Review articles from the 5th International Meeting of the IASP Special Interest Group on Neuropathic Pain (NeuPSIG); International audience; Pain is a quite frequent complaint accompanying numerous pathologies. Among these pathological cases, numerous neuropathies are retrieved with identified etiologies (chemotherapies, diabetes, surgeries…) and also more diffuse syndromes such as fibromyalgia. More broadly, pain is one of the first consequences of most inherited diseases. Despite its importance for the quality of life, current pain management is limited to drugs that are either old or with a limited efficacy or that possess a bad risk benefit ratio. As no new pharmacological concept has led to new analgesics in the last decades, the discovery of new medications is needed, and to this aim, the identification of new druggable targets in pain transmission is a first step. Therefore, studies of ion channels in pain pathways are extremely active. This is particularly true with ion channels in peripheral sensory neurons in dorsal root ganglia known how to express unique sets of these channels. Moreover, both spinal and supraspinal levels are clearly important in pain modulation. Among these ion channels, we and others revealed the important role of low voltage-gated calcium channels in cellular excitability in different steps of the pain pathways. These channels, by being activated nearby resting membrane potential, have biophysical characteristics suited to facilitate action potential generation and rhythmicity. In this review, we will present the current knowledge on the role of these channels in the perception and modulation of pain. |
| Databáze: | OpenAIRE |
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