Benign Solitary Fibrous Histiocytoma of Xanthomatous Subtype of the Perilimbal Conjunctiva and Adjacent Sclera in a Youth
| Autor: | Tina Tang, Tatyana Milman, Seymour Brownstein, Michael O'Connor, Andre Ali-Ridha |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Pathology
medicine.medical_specialty Conjunctiva Benign fibrous histiocytoma business.industry CD34 medicine.disease eye diseases Sclera Lesion 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Novel Insights from Clinical Practice Giant cell 030220 oncology & carcinogenesis 030221 ophthalmology & optometry medicine Immunohistochemistry sense organs medicine.symptom business Positive staining General Nursing |
| Zdroj: | Ocular Oncology and Pathology. 4:341-344 |
| ISSN: | 2296-4657 2296-4681 |
| DOI: | 10.1159/000486421 |
| Popis: | Aims: To report the clinical and pathological features of a benign fibrous histiocytoma of the xanthomatous subtype in the perilimbal conjunctiva and adjacent sclera in a youth. Methods: An 11-year-old Caucasian boy presented with a yellowish dome-shaped conjunctival mass abutting the inferotemporal limbus of the left eye. The tumor measured 4 mm in its maximum diameter. The lesion was excised and was noted to extend into the sclera. Three years postoperatively, there was no evidence of recurrence. Results: Histopathological examination disclosed a highly cellular lesion composed predominantly of benign-appearing foamy histiocytes without multinucleated giant cells. The tumor contained sparse fibrous septa without a storiform configuration. Immunohistochemical analysis showed diffuse cytoplasmic positive staining with adipophilin, CD34, and CD163. Conclusion: A lesion comprised of numerous homogeneous foamy histiocytes without multinucleated giant cells in the perilimbal conjunctiva and adjacent sclera of a youth is presented as a unique case of a rare variant of fibrous histiocytoma of the xanthomatous subtype. |
| Databáze: | OpenAIRE |
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