PGF2α and breathing pattern in newborn pigs
| Autor: | M.G. Clement, G. Aguggini, Mariangela Albertini |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Atropine
Male medicine.medical_specialty Respiratory rate Swine Indomethacin Clinical Biochemistry Prostaglandin Alpha (ethology) Dinoprost chemistry.chemical_compound Breathing pattern Internal medicine Respiration medicine Animals Anesthesia Aerosols Hypoventilation Cell Biology respiratory system Respiratory activity Endocrinology Animals Newborn chemistry Female lipids (amino acids peptides and proteins) medicine.symptom Pulmonary Ventilation medicine.drug |
| Zdroj: | Prostaglandins, Leukotrienes and Essential Fatty Acids. 40:103-107 |
| ISSN: | 0952-3278 |
| Popis: | The effect of PGF2 alpha has been evaluated in 11 unanaesthetized unrestrained piglets and in 3 anaesthetized piglets (2-3 days old) using a barometric-plethysmographic technique. PGF2 alpha (mg 0.25/pig) was administered as aerosol for 5 min. In 3 of the unanaesthetized newborn pigs the effect of PGF2 alpha aerosol has been evaluated after indomethacin (mg 1/Kg i.v.). The vagal dependent activity of the prostaglandin was also evaluated after atropine (mg 0.08/Kg i.m.). Our results show that PGF2 alpha in newborn pigs causes hypoventilation due to a decrease in respiratory rate and to a lengthening in TE. The changes in TE are due to an increase in the incidence and duration of apneic events characterizing the respiratory activity at birth. After indomethacin PGF2 alpha does not change the breathing pattern. Atropine only partially reduces the effects of PGF2 alpha while, after anaesthesia, prostaglandin does not change the breathing pattern. Consequently our results show that PGF2 alpha in newborn animals similar to other prostaglandins acts as a depressant of respiratory activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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