NMDA receptors in the avian amygdala and the premotor arcopallium mediate distinct aspects of appetitive extinction learning
| Autor: | Onur Güntürkün, Daniel Lengersdorf, Maik C. Stüttgen, Meng Gao |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Arcopallium Biology Receptors N-Methyl-D-Aspartate Amygdala Extinction Psychological 03 medical and health sciences Behavioral Neuroscience Catheters Indwelling 0302 clinical medicine Animal model Conditioning Psychological medicine Animals Fear conditioning Columbidae Memory Consolidation Cued speech Analysis of Variance Appetitive Behavior Brain social sciences Extinction (psychology) humanities 030104 developmental biology medicine.anatomical_structure 2-Amino-5-phosphonovalerate Mental Recall Models Animal Extinction memory NMDA receptor Excitatory Amino Acid Antagonists Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Behavioural Brain Research. 343:71-82 |
| ISSN: | 0166-4328 |
| DOI: | 10.1016/j.bbr.2018.01.026 |
| Popis: | Extinction learning is an essential mechanism that enables constant adaptation to ever-changing environmental conditions. The underlying neural circuit is mostly studied with rodent models using auditory cued fear conditioning. In order to uncover the variant and the invariant neural properties of extinction learning, we adopted pigeons as an animal model in an appetitive sign-tracking paradigm. The animals firstly learned to respond to two conditioned stimuli in two different contexts (CS-1 in context A and CS-2 in context B), before conditioned responses to the stimuli were extinguished in the opposite contexts (CS-1 in context B and CS-2 in context A). Subsequently, responding to both stimuli was tested in both contexts. Prior to extinction training, we locally injected the N-methyl-d-aspartate receptor (NMDAR) antagonist 2-Amino-5-phosphonovaleric acid (APV) in either the amygdala or the (pre)motor arcopallium to investigate their involvement in extinction learning. Our findings suggest that the encoding of extinction memory required the activation of amygdala, as visible by an impairment of extinction acquisition by concurrent inactivation of local NMDARs. In contrast, consolidation and subsequent retrieval of extinction memory recruited the (pre)motor arcopallium. Also, the inactivation of arcopallial NMDARs induced a general motoric slowing during extinction training. Thus, our results reveal a double dissociation between arcopallium and amygdala with respect to acquisition and consolidation of extinction, respectively. Our study therefore provides new insights on the two key components of the avian extinction network and their resemblance to the data obtained from mammals, possibly indicating a shared neural mechanism underlying extinction learning shaped by evolution. |
| Databáze: | OpenAIRE |
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