New Pyridinium Alkaloids from a Marine Sponge of the GenusSpongiawith a Human Phospholipase A2Inhibitor Profile
| Autor: | Franco Zollo, Alcaraz Mj, De Marino S, Cécile Debitus, M. Paya, Maria Iorizzi, L. F. Ospina, J. L. Menou |
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| Přispěvatelé: | DE MARINO, Simona, M., Iorizzi, Zollo, Franco, C., Debitu, J. L., Menou, L. F., Ospina, M. J., Alcaraz, M., Paya |
| Rok vydání: | 2000 |
| Předmět: |
Pharmacology
Phospholipase A biology Stereochemistry Alkaloid Organic Chemistry Pharmaceutical Science Pharmacognosy biology.organism_classification Animal origin Spongia Analytical Chemistry Sponge chemistry.chemical_compound Complementary and alternative medicine chemistry Genus Drug Discovery Molecular Medicine Organic chemistry Pyridinium |
| Zdroj: | Journal of Natural Products. 63:322-326 |
| ISSN: | 1520-6025 0163-3864 |
| Popis: | Four new bioactive pyridinium alkaloids, named spongidines A-D (5-8), have been isolated from a Vanuatu sponge of the genus Spongia, together with known petrosaspongiolides D (1) and G (2). Compounds 3 and 4 are 21-hydroxy derivatives of petrosaspongiolides K and P. Structure elucidation was accomplished through extensive 2D NMR experiments and IR, UV, and FABMS data. All compounds significantly inhibited human synovial phospholipase A(2) (PLA(2)) at 10 mu M, with, an IC50 value of 5.8 mu M for compound 4, which is the most potent inhibitor, with a higher selectivity toward this enzyme than the reference inhibitor manoalide. Pyridinium alkaloids (5-8) mainly inhibited human synovial PLA(2). Compound 8, which contains a sulfonic acid group, is the most interesting inhibitor. |
| Databáze: | OpenAIRE |
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