Langerhans cell activation in diabetic small fiber polyneuropathy
| Autor: | Ja Nean K. Engelstad, Ezequiel A. Piccione, Carilyn N. Wieland, Christopher J. Klein |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Pathology
medicine.medical_specialty Langerhans cell integumentary system medicine.diagnostic_test business.industry Nerve fiber Type 2 diabetes Thigh medicine.disease 3. Good health medicine.anatomical_structure Allodynia Neurology Skin biopsy medicine Neurology (clinical) Fiber medicine.symptom business Polyneuropathy Clinical/Scientific Notes |
| Zdroj: | Neurology® Neuroimmunology & Neuroinflammation |
| ISSN: | 2332-7812 |
| Popis: | A 63-year-old man with type 2 diabetes developed painful feet with touch allodynia. Skin biopsy revealed prominent Langerhans cells (LC) staining with the standard epidermal nerve fiber antibody PGP9.5 when compared to a normal control (figure). Fiber density was severely decreased at the leg (mean 0.2 fibers/mm, 95% confidence interval [CI] 0.1–0.4) and thigh (mean 2.2 fibers/mm, 95% CI 1.8–2.8). These findings were consistent with small fiber neuropathy. |
| Databáze: | OpenAIRE |
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