The effect of propofol on patient reaction time and its relationship with loss of verbal contact before induction of anaesthesia*
| Autor: | R. M. Chapman, K. J. Anderson, Gavin N. C. Kenny, S. Allam |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Auditory response Sedation Pilot Projects Self Administration Anesthesia General Reaction Time medicine Humans Speech General anaesthesia Propofol Patient reaction Dose-Response Relationship Drug Choice reaction time business.industry Analgesia Patient-Controlled Anesthesiology and Pain Medicine Anesthesia Plasma concentration Female medicine.symptom business Anesthetics Intravenous medicine.drug |
| Zdroj: | Anaesthesia. 68:148-153 |
| ISSN: | 1365-2044 0003-2409 |
| Popis: | Summary Increasing the calculated plasma concentration of propofol has been shown to increase choice reaction time and visual and auditory response times. We studied the relationship of reaction to a vibrating handset as the effect-site target-controlled propofol concentration was incrementally increased in 20 patients during sedation, before induction of general anaesthesia. The reaction time increased, initially slowly and then more rapidly, as the calculated effect-site concentration of propofol increased, until the reaction to the vibrating handset was lost at a mean (SD) propofol effect-site concentration of 2.0 (0.6) μg.ml−1. The loss of response to verbal contact occurred at a propofol effect-site concentration of 2.4 (0.5) μg.ml−1. Reaction time may be of use clinically to warn of impending loss of verbal contact. |
| Databáze: | OpenAIRE |
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