Marine-Derived Compounds for the Potential Treatment of Glucocorticoid Resistance in Severe Asthma
| Autor: | Cristina Mihaela Ghiciuc, Sabina A Antoniu, Paraschiva Postolache, Andrei Gheorghe Vicovan, Celina Stafie |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
severe asthma
biomedical applications Aquatic Organisms QH301-705.5 Severe asthma Anti-Inflammatory Agents Drug Resistance Pharmaceutical Science Review Bioinformatics Severity of Illness Index Drug Discovery glucocorticoid-resistant medicine Animals Humans Biology (General) Glucocorticoids Pharmacology Toxicology and Pharmaceutics (miscellaneous) Asthma Biological Products business.industry Biological activity medicine.disease drug development Response to treatment marine-derived compounds Drug development Molecular mechanism Glucocorticoid Resistance business Glucocorticoid medicine.drug |
| Zdroj: | Marine Drugs Marine Drugs, Vol 19, Iss 586, p 586 (2021) |
| ISSN: | 1660-3397 |
| DOI: | 10.3390/md19110586 |
| Popis: | One of the challenges to the management of severe asthma is the poor therapeutic response to treatment with glucocorticosteroids. Compounds derived from marine sources have received increasing interest in recent years due to their prominent biologically active properties for biomedical applications, as well as their sustainability and safety for drug development. Based on the pathobiological features associated with glucocorticoid resistance in severe asthma, many studies have already described many glucocorticoid resistance mechanisms as potential therapeutic targets. On the other hand, in the last decade, many studies described the potentially anti-inflammatory effects of marine-derived biologically active compounds. Analyzing the underlying anti-inflammatory mechanisms of action for these marine-derived biologically active compounds, we observed some of the targeted pathogenic molecular mechanisms similar to those described in glucocorticoid (GC) resistant asthma. This article gathers the marine-derived compounds targeting pathogenic molecular mechanism involved in GC resistant asthma and provides a basis for the development of effective marine-derived drugs. |
| Databáze: | OpenAIRE |
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