Inhibition of basic fibroblast growth factor-induced growth promotion by overexpression of syndecan-1
| Autor: | Klaus Elenius, Heini M. Miettinen, Markku Mali, Markku Jalkanen |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Syndecans
animal structures Molecular Sequence Data Basic fibroblast growth factor Down-Regulation Transfection Fibroblast growth factor Biochemistry Mice chemistry.chemical_compound Animals Growth factor receptor inhibitor Molecular Biology DNA Primers Binding Sites Membrane Glycoproteins Base Sequence biology Heparin Fibroblast growth factor receptor 2 3T3 Cells Cell Biology Fibroblast growth factor receptor 4 Fibroblast growth factor receptor 3 Extracellular Matrix Fibronectins Cell biology carbohydrates (lipids) chemistry Fibroblast growth factor receptor embryonic structures biology.protein Fibroblast Growth Factor 2 Proteoglycans Syndecan-1 Cell Division Platelet-derived growth factor receptor |
| Zdroj: | Journal of Biological Chemistry. 268:24215-24222 |
| ISSN: | 0021-9258 |
| DOI: | 10.1016/s0021-9258(20)80513-4 |
| Popis: | The expression of syndecan-1, the prototype member of the cell surface proteoglycan family, follows morphogenetic rather than histological boundaries during organ formation. As a heparan sulfate-containing cell surface molecule, syndecan-1 can simultaneously bind various components of the extracellular matrix and members of the heparin-binding growth factors. Indeed, syndecan-1 may act as a co-receptor for basic fibroblast growth factor (bFGF) (Salmivirta, M., Heino, J., and Jalkanen, M. (1992) J. Biol. Chem. 267, 17606-17610), allowing the growth factor to bind the tyrosine kinase bFGF receptor. We have studied the role of syndecan-1 in growth factor response by growing 3T3 cells transfected with syndecan-1 in the presence of bFGF. The enhanced expression of syndecan-1 caused down-regulation of bFGF-induced cell proliferation and, at the same time, enhancement of cell matrix interactions. Thus, the induced expression of the heparan sulfate co-receptor (syndecan-1) may provide a mechanism to restrict FGF action and modulate cell-matrix interactions to maintain co-ordinated growth of cells during organ formation. |
| Databáze: | OpenAIRE |
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