Differential effects of aprotinin and tranexamic acid on outcomes and cytokine profiles in neonates undergoing cardiac surgery

Autor: Stacia M. DeSantis, A Lauren Haney, Francis G. Spinale, Andrew M. Atz, Rachael L. Deardorff, Eric M. Graham, Scott M. Bradley, Scott Reeves, Walter E. Uber, Jenna F Gillis, Francis X. McGowan
Rok vydání: 2012
Předmět:
Heart Defects
Congenital
Male
Pulmonary and Respiratory Medicine
Time Factors
South Carolina
Blood Loss
Surgical
Factor VIIa
Platelet Transfusion
Postoperative Hemorrhage
Risk Assessment
Article
Aprotinin
Risk Factors
Blood product
Antifibrinolytic agent
medicine
Humans
Cardiac Surgical Procedures
Retrospective Studies
Analysis of Variance
Chi-Square Distribution
Tumor Necrosis Factor-alpha
business.industry
Age Factors
Infant
Newborn
Acute kidney injury
Perioperative
medicine.disease
Hospital Charges
Respiration
Artificial
Antifibrinolytic Agents
Recombinant Proteins
Treatment Outcome
Platelet transfusion
Tranexamic Acid
Anesthesia
Cryoprecipitate
Cytokines
Interleukin-2
Female
Surgery
Inflammation Mediators
Erythrocyte Transfusion
Cardiology and Cardiovascular Medicine
business
Tranexamic acid
medicine.drug
Zdroj: The Journal of Thoracic and Cardiovascular Surgery. 143:1069-1076
ISSN: 0022-5223
DOI: 10.1016/j.jtcvs.2011.08.051
Popis: ObjectiveFactors contributing to postoperative complications include blood loss and a heightened inflammatory response. The objective of this study was to test the hypothesis that aprotinin would decrease perioperative blood product use, reduce biomarkers of inflammation, and result in improved clinical outcome parameters in neonates undergoing cardiac operations.MethodsThis was a secondary retrospective analysis of a clinical trial whereby neonates undergoing cardiac surgery received either aprotinin (n = 34; before May 2008) or tranexamic acid (n = 42; after May 2008). Perioperative blood product use, clinical course, and measurements of cytokines were compared.ResultsUse of perioperative red blood cells, cryoprecipitate, and platelets was reduced in neonates receiving aprotinin compared with tranexamic acid (P
Databáze: OpenAIRE
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