Designing antioxidant peptides based on the antioxidant properties of the amino acid side-chains
| Autor: | Risa Honda, Tomoka Togitani, Riko Matsui, Mutsumi Kanome, Yuka Matsuda, Akari Hagiwara, Narumi Ikemoto, Masaaki Terashima |
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| Rok vydání: | 2017 |
| Předmět: |
0106 biological sciences
Antioxidant medicine.medical_treatment Peptide Protein Engineering 01 natural sciences Antioxidants Analytical Chemistry chemistry.chemical_compound Structure-Activity Relationship 0404 agricultural biotechnology 010608 biotechnology Peroxynitrous Acid medicine Tyrosine Amino Acids Reactive nitrogen species chemistry.chemical_classification Reactive oxygen species Myoglobin Tryptophan 04 agricultural and veterinary sciences General Medicine 040401 food science Reactive Nitrogen Species Amino acid Peroxides chemistry Biochemistry Peptides Reactive Oxygen Species Hydrophobic and Hydrophilic Interactions Peroxynitrite Food Science |
| Zdroj: | Food chemistry. 245 |
| ISSN: | 1873-7072 |
| Popis: | Amino acids exert characteristic antioxidant activities depending on the properties of their side residues. The hydrophobic residues were effective against peroxyl radical, while acidic residues and their analogs were effective against peroxynitrite. Peptides containing tyrosine showed different activities against different reactive oxygen species (ROS) and/or reactive nitrogen species (RNS). The number and position of tyrosine did not affect the antioxidant activity against hypochlorite ion. Against the peroxyl radical, the number of tyrosine residues affected the antioxidant activity, while its position did not have a significant effect. The tyrosine position was an important factor for the antioxidant activity against peroxynitrite. The peptide GWWW showed higher antioxidant activity against peroxyl radical than tryptophan at concentrations below 25 µM, and high activity against peroxynitrite at 250 µM. Our results suggest that antioxidant peptides against a specific target ROS or RNS can be designed based on the characteristics of the amino acid side chains. |
| Databáze: | OpenAIRE |
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