Visual monitoring and optical recognition of digoxin by functionalized AuNPs and triangular AgNPs as efficient optical nano-probes
| Autor: | Paria Pashazadeh-Panahi, Mohammad Hasanzadeh, Arezoo Mohammadzadeh |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Digoxin
Cysteamine Nanoparticle Metal Nanoparticles 010402 general chemistry 01 natural sciences Sensitivity and Specificity Silver nanoparticle chemistry.chemical_compound Structural Biology Limit of Detection Spectrophotometry polycyclic compounds medicine Humans Hydrogen peroxide Molecular Biology Detection limit medicine.diagnostic_test Benzidines 010401 analytical chemistry Hydrogen Peroxide 0104 chemical sciences chemistry Linear range Molecular Probes Amine gas treating Chemical binding Colorimetry Spectrophotometry Ultraviolet Gold Nuclear chemistry |
| Zdroj: | Journal of molecular recognition : JMRREFERENCES. 34(10) |
| ISSN: | 1099-1352 |
| Popis: | In this study, we presented elective, sensitive, and rapid UV-Vis spectrophotometry and calorimetric assay for the recognition of digoxin. Therefore, cysteamine-gold nanoparticles (Cys A-AuNPs) in the presence of cysteine acid amine and Silver nanoparticles in the presence of tetramethyl benzidine and hydrogen peroxide (AgNPs-TMB [3,3',5,5'-tetramethylbenzidine]-H2 O2 ) were synthesized and utilized as the desired probe. Finally, color variation of probes was observed in the absence and presence of digoxin. Obtained results indicate that the color of Cys A-AuNPs changed from dark pink to light in the absence and the presence of digoxin, respectively. Also, the color of AgNPs-TMB-H2 O2 changed from dark blue to light blue, in the absence and the presence of digoxin, respectively. Moreover, UV-Vis spectroscopies results indicate digoxin with a low limit of quantification of 0.125 ppm in human plasma samples which linear range was 0.125 to 11 ppm. |
| Databáze: | OpenAIRE |
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