Flavonoids with Activity against Methicillin-Resistant Staphylococcus aureus from Dalea scandens var. paucifolia
| Autor: | N. P. Dhammika Nanayakkara, Charles L. Burandt, Melissa R. Jacob |
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| Rok vydání: | 2002 |
| Předmět: |
Staphylococcus aureus
Magnetic Resonance Spectroscopy Flavonoid Pharmaceutical Science Microbial Sensitivity Tests Penicillins Biology Pharmacognosy medicine.disease_cause Plant Roots Analytical Chemistry Inhibitory Concentration 50 Methicillin Drug Discovery Botany medicine Inhibitory concentration 50 Antibacterial agent Flavonoids Pharmacology Dalea scandens chemistry.chemical_classification Molecular Structure Plant Extracts Organic Chemistry Fabaceae Methicillin-resistant Staphylococcus aureus Complementary and alternative medicine chemistry Flavanones Molecular Medicine Methicillin Resistance |
| Zdroj: | Planta Medica. 68:519-522 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/s-2002-32554 |
| Popis: | Bioassay-guided fractionation of the ethyl acetate extract of the roots of Dalea scandens (Miller) R. Clausen var. paucifolia led to the isolation of new flavonoids, 2( S)-5'-(-1"',1"'-dimethylallyl)-8-(3",3"-dimethylallyl)-2',4',5,7-tetrahydroxyflavanone, 2( S)-5'-(1"',1"'-dimethylallyl)-8-(3",3"-dimethylallyl)-2'-methoxy-4',5,7-trihydroxyflavanone and 5'-(1"',1"'-dimethylallyl)-8-(3",3"-dimethylallyl)-2',4',5,7-tetrahydroxyflavone. Structure elucidation was carried out by spectroscopic methods. All three compounds showed significant activity against both methicillin-susceptible and methicillin-resistant Staphylococcus aureus. |
| Databáze: | OpenAIRE |
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