Decreased serum selenium concentrations in patients with Parkinson's disease
| Autor: | F. Cabrera-Valdivia, M. V. Aguilar, A. Vazquez, José Antonio Molina, P. Fernández-Calle, F J Jiménez-Jiménez, V. Seijas, F.J. Arrieta, A. Jorge-Santamaría, M.C. Martínez-Para |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Antioxidant Parkinson's disease business.industry medicine.medical_treatment Glutathione peroxidase Urinary system chemistry.chemical_element Substantia nigra medicine.disease_cause medicine.disease Excretion Endocrinology Neurology chemistry Internal medicine medicine Neurology (clinical) business Oxidative stress Selenium |
| Zdroj: | European journal of neurology. 2(2) |
| ISSN: | 1351-5101 |
| Popis: | Selenium is an essential component of the antioxidant enzyme glutathione peroxidase. The activity of this enzyme is reduced in the substantia nigra of patients with Parkinson's disease (PD), but the results of studies on erythrocytes are controversial. We compared the serum levels of selenium and the 24 h urinary selenium excretion (measured by hydride generation atomic absorption spectrophotometry) in 29 PD patients and 30 matched controls. Serum selenium levels were significantly lower in PD patients than in controls (34.6 ± 2.35 and 45.2 ± 3.83 μg/l, p < 0.05) while urinary excretion was similar for both groups (47.1 ± 6.25 and 45.5 ± 5.38 μg/24 h). These values were not influenced by antiparkinsonian drugs, and they did not correlate with age, age at onset and duration of the PD, scores of the Unified PD Rating Scale or the Hoehn and Yahr staging in the PD group. These results might suggest a possible role of low serum selenium levels in the risk for, or a consequence of the oxidative stress in PD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text