In vitroactivity of CAY-1, a saponin fromCapsicum frutescens, againstMicrosporumandTrichophytonspecies
| Autor: | Anthony J. De Lucca, Thomas J. Walsh, Joseph Meletiadis, Emmanuel Roilides, Theodouli Stergiopoulou, Mahmoud A. Ghannoum, Stephen M. Boue, Tin Sein, Robert L. Schaufele |
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| Rok vydání: | 2008 |
| Předmět: |
Hyphae
Microbial Sensitivity Tests medicine.disease_cause Article Microbiology Conidium food Trichophyton medicine Microsporum Microsporum canis Candida albicans biology Arthrodermataceae fungi General Medicine Saponins Spores Fungal biology.organism_classification food.food Cayenne pepper Infectious Diseases Dermatophyte Regression Analysis Steroids Capsicum |
| Zdroj: | Medical Mycology. 46:805-810 |
| ISSN: | 1460-2709 1369-3786 |
| DOI: | 10.1080/13693780802089831 |
| Popis: | Dermatomycoses are among the world's most common diseases and their incidence has increased over recent years, particularly in immunosuppressed patients. In previous studies, the saponin CAY-1 from cayenne pepper (Capsicum frutescens), has shown antifungal activities against Candida albicans and Aspergillus spp. We therefore studied the in vitro antifungal activity of CAY-1 against non-germinating conidia and hyphae of clinical isolates of the dermatophytes Trichophyton mentagrophytes, T. rubrum, T. tonsurans and Microsporum canis. We used a microdilution method to assess the growth inhibitory activities of CAY-1 against conidia (CLSI document M38-A) and a colorimetric procedure (XTT method) to investigate the metabolic inhibitory activity of CAY-1 against hyphae. The minimal inhibitory concentrations (complete visual growth inhibition) of CAY-1 against non-germinating conidia ranged from 10-20 microg/ml for all dermatophyte isolates included in this investigation. In addition, we found >90% inhibition of hyphal metabolic activity of these same isolates with 10-20 microg/ml of CAY-1. Results indicate that CAY-1 merits further investigation as a potential agent for the treatment of dermatomycoses. |
| Databáze: | OpenAIRE |
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