Adjusting vascular permeability, leukocyte infiltration, and microglial cell activation to rescue dopaminergic neurons in rodent models of Parkinson’s disease
| Autor: | Hong Jiang, Hua-Ying Cai, Xiao-Xiao Fu, Shu Han |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Cell biology
Parkinson's disease business.industry Dopaminergic Inflammation Vascular permeability Pharmacology medicine.disease Neuroprotection Article Cellular neuroscience Cellular and Molecular Neuroscience Microglial cell activation medicine.anatomical_structure Neurology Medicine Neurology. Diseases of the nervous system Neurology (clinical) medicine.symptom RC346-429 business Infiltration (medical) Blood vessel |
| Zdroj: | NPJ Parkinson's Disease npj Parkinson's Disease, Vol 7, Iss 1, Pp 1-16 (2021) |
| ISSN: | 2373-8057 |
| Popis: | Animal studies have indicated that increased blood-brain barrier (BBB) permeability and inflammatory cell infiltration are involved during the progression of Parkinson’s disease (PD). This study used C16, a peptide that competitively binds to integrin αvβ3 and inhibits inflammatory cell infiltration, as well as angiopoietin-1 (Ang-1), an endothelial growth factor crucial for blood vessel protection, to reduce inflammation and improve the central nervous system (CNS) microenvironment in murine models of PD. The combination of C16 and Ang-1 yielded better results compared to the individual drugs alone in terms of reducing dopaminergic neuronal apoptosis, ameliorating cognitive impairment, and electrophysiological dysfunction, attenuating inflammation in the CNS microenvironment, and improving the functional disability in PD mice or rats. These results suggest neuroprotective and anti-inflammatory properties of the C16 peptide plus Ang-1 in PD. |
| Databáze: | OpenAIRE |
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