Antibiotic Susceptibility of Cutibacterium acnes Strains Isolated from Israeli Acne Patients
| Autor: | Vanda Lerer, Tehila Shlomov, Amit Rimon, Chani Rakov, Sivan Sheffer-Levi, Ronen Hazan, Ran Nir-Paz, Tamara Zeiter, Shunit Coppenhagen-Glazer, Vered Molho-Pessach |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.drug_class Tetracycline 030106 microbiology Antibiotics Erythromycin Microbial Sensitivity Tests Dermatology Microbiology resistance 03 medical and health sciences Antibiotic resistance RNA Ribosomal 16S antibiotic Acne Vulgaris lcsh:Dermatology medicine Humans Propionibacterium acnes Israel acne Etest Doxycycline business.industry Clindamycin General Medicine Minocycline lcsh:RL1-803 cutibacterium acnes Anti-Bacterial Agents 030104 developmental biology business medicine.drug |
| Zdroj: | Acta Dermato-Venereologica, Vol 100, Iss 17, p adv00295 (2020) |
| ISSN: | 1651-2057 |
| DOI: | 10.2340/00015555-3654 |
| Popis: | Antibiotic-resistant Cutibacterium acnes has been reported worldwide, but data from Israeli patients with acne is currently lacking. This study evaluated the antibiotic susceptibility of C. acnes, isolated from 50 Israeli patients with acne to commonly prescribed antibiotics, using the Epsilometer test (E-test). Matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) analysis, 16S rRNA sequencing and single locus sequence typing (SLST) molecular typing were used to identify and characterize C. acnes. Among 36 strains isolated, phylotype IA1 was most common. Resistance to at least one antibiotic was found in 30.6% of tested strains. Resistance rates were highest for erythromycin (25.0%), followed by doxycycline (19.4%), clindamycin (16.7%), minocycline (11.1%) and tetracycline (8.3%). Significant correlation was found between resistance to multiple antibiotics, with 5.6% of isolates resistant to all antibiotics tested. When reviewing resistances rate worldwide antibiotic resistance was found to be prevalent in Israel. Measures to limit the emergence of antibiotic-resistant strains of Cutibacterium acnes should be taken and alternative treatments should be sought. |
| Databáze: | OpenAIRE |
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