Enhanced urinary excretion of cysteinyl leukotrienes in patients with acute alcohol intoxication
| Autor: | Andrea Keppler-Hafkemeyer, Wolf-dieter Lehmann, Hiroshi Fukui, Dietrich Keppler, Winfried Schneider, Masao Fujimoto, Masahito Uemura, Tadasu Tsujii, Peter Hafkemeyer, Hideyuki Kojima, Axel Benner, Helmut K. Seitz |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male medicine.medical_specialty Alcohol Drinking Leukotriene B4 Poison control Urine Excretion chemistry.chemical_compound Liver Function Tests Liver Cirrhosis Alcoholic Internal medicine medicine Humans Cysteine Chromatography High Pressure Liquid Leukotriene E4 Leukotriene Creatinine Ethanol Hepatology Gastroenterology Central Nervous System Depressants Middle Aged Endocrinology chemistry Biochemistry Acute Disease Female Alcoholic Intoxication |
| Zdroj: | Gastroenterology. 118(6) |
| ISSN: | 0016-5085 |
| Popis: | Leukotrienes are proinflammatory mediators. Ethanol inhibits the catabolism of both cysteinyl leukotrienes (leukotriene E(4) [LTE(4)] and N-acetyl-LTE(4)) and leukotriene B(4) (LTB(4)) in hepatocytes. We examined the metabolic derangement of leukotriene inactivation by ethanol in humans in vivo.LTE(4), N-acetyl-LTE(4), LTB(4), and 20-hydroxy-LTB(4) were quantified in urine samples from 16 patients with acute alcohol intoxication (mean blood ethanol, 75 mmol/L). In 9 healthy volunteers, urinary LTE(4) was determined before and after ethanol consumption (mean blood ethanol, 14 mmol/L).The excretion of LTE(4) during alcohol intoxication was 286 compared with 36 nmol/mol creatinine in healthy subjects (P0.01); the corresponding values for N-acetyl-LTE(4) were 101 and 11 nmol/mol creatinine, respectively (P0.001). This excretion of cysteinyl leukotrienes decreased when the blood ethanol concentration returned to normal. LTB(4) and 20-hydroxy-LTB(4) were detectable only in patients with excessive blood ethanol concentrations (mean, 95 mmol/L). In healthy volunteers, LTE(4) excretion increased 3-5 hours after ethanol consumption (mean peak concentration of 1.5 nmol/L compared with 0.5 nmol/L for basal values; P0.005).Ethanol at high concentration induces increased leukotriene excretion into urine. These changes are consistent with inhibition of leukotriene catabolism and inactivation induced by ethanol, as well as with a higher leukotriene formation caused by ethanol-induced endotoxemia. |
| Databáze: | OpenAIRE |
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