Antibacterial activity of some natural products against bacteria expressing a multidrug-resistant phenotype
| Autor: | A. E. Nkengfack, Victor Kuete, Jacqueline Chevalier, Jean Gustave Tangmouo, Gabriel N. Folefoc, Kenneth Oben Eyong, Sandrine Alibert-Franco, Bathelemy Ngameni, Justin Komguem, Jean Robert Nguemeving, Jean-Michel Bolla, Ghislain W. Fotso, Bonaventure T. Ngadjui, B. M. W. Ouahouo, Jean-Marie Pagès |
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| Přispěvatelé: | Faculty of Science, Université de Dschang, University of Yaoundé [Cameroun], Faculty of Medicine and Biomedical Science |
| Rok vydání: | 2011 |
| Předmět: |
Microbiology (medical)
Gram-negative bacteria Terpenoids Multidrug resistance Microbiology 03 medical and health sciences chemistry.chemical_compound Alkaloids Phenols Drug Resistance Multiple Bacterial Antibacterial activities Gram-Negative Bacteria Humans Pharmacology (medical) 030304 developmental biology Antibacterial agent Biological Products 0303 health sciences biology Terpenes 030306 microbiology Membrane Transport Proteins Biological Transport General Medicine Plumbagin biology.organism_classification Antimicrobial Naphthoquinone Anti-Bacterial Agents Multiple drug resistance Infectious Diseases Biochemistry chemistry Efflux Phenolics Efflux pump inhibitor Bacteria |
| Zdroj: | International Journal of Antimicrobial Agents International Journal of Antimicrobial Agents, Elsevier, 2011, 37 (2), pp.156. ⟨10.1016/j.ijantimicag.2010.10.020⟩ |
| ISSN: | 0924-8579 |
| Popis: | International audience; The present study assessed the antimicrobial activities of various natural products belonging to the terpenoids, alkaloids and phenolics against a collection of Gram-negative multidrug-resistant (MDR) bacteria. The results demonstrated that most of the compounds were extruded by bacterial efflux pumps. In the presence of the efflux pump inhibitor phenylalanine arginine β-naphthylamide (PAβN), the activities of laurentixanthone B (xanthone), plumbagin (naphthoquinone), 4-hydroxylonchocarpin (flavonoid) and MAB3 (coumarin) increased significantly against all studied MDR bacteria. Laurentixanthone B, 4-hydroxylonchocarpin and MAB3 contained the same pharmacophoric moiety as plumbagin. This study indicates that the AcrAB-TolC (Enterobacteriaceae) and MexAB-OprM () efflux pumps are involved in resistance of Gram-negative bacteria to most of the natural products. |
| Databáze: | OpenAIRE |
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