Association of lewy bodies, hippocampal sclerosis and amyloid angiopathy with dementia in community-dwelling elderly: A systematic review and meta-analysis
| Autor: | M. Reza Azarpazhooh, Lauren E. Cipriano, Mahdiyeh Erfanian, Naghmeh Mokhber, Shahram Abootalebi, Amin Amiri, Golnaz Shojaeianbabaei, Saverio Stranges, Abolfazl Avan |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Autopsy Hippocampus Physiology (medical) Internal medicine mental disorders medicine Prevalence Dementia Humans Aged Aged 80 and over Hippocampal sclerosis Sclerosis Lewy body business.industry Absolute risk reduction General Medicine medicine.disease Confidence interval Cerebral Amyloid Angiopathy Neurology Meta-analysis Surgery Female Lewy Bodies Neurology (clinical) Cerebral amyloid angiopathy Independent Living business |
| Zdroj: | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 90 |
| ISSN: | 1532-2653 |
| Popis: | Introduction We measured the proportion of Lewy body pathology (LB), hippocampal sclerosis (HS), and cerebral amyloid angiopathy (CAA) among community-dwelling people with and without dementia. Methods We searched for community-based cohorts with postmortem brain autopsy until 1 January 2020. We calculated the summary risk difference and 95% confidence interval (95% CI) using a random-effects model in R. Results We found 12 articles, comprising 2197 demented and 2104 non-demented participants. LB, HS, CAA were prevalent lesions among community-dwelling elderly (15%, 10%, and 24%, respectively). These significantly increased the risk of dementia (LB: risk difference 38%, 95% CI 20–56%, HS: 34%, 24–44%, CAA: 19%, 3–34%). 20% of cases with neocortical LB, 17% with bilateral HS, and 42% with moderate/severe CAA pathology remained non-demented by death. Discussion LB or HS or CAA are common neuropathologies among community-dwelling elderly. Although these lesions independently are associated with dementia, many remain non-demented, by death. |
| Databáze: | OpenAIRE |
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