Alternative staging of regional lymph nodes in gastric cancer
Autor: | Agata Paszko, Thecla Scully-Horner, Antoni M. Szczepanik, Mirosław Szura, Jan Kulig |
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Rok vydání: | 2016 |
Předmět: |
medicine.medical_specialty
Pathology Prognostic factor medicine.medical_treatment lymph node staging 03 medical and health sciences 0302 clinical medicine medicine Stage (cooking) Lymph node Negative Lymph Node Review Paper business.industry gastric cancer Gastroenterology Cancer medicine.disease Stage migration medicine.anatomical_structure 030220 oncology & carcinogenesis lymphadenectomy 030211 gastroenterology & hepatology Lymphadenectomy Radiology Lymph business |
Zdroj: | Przegla̜d Gastroenterologiczny |
ISSN: | 1895-5770 |
Popis: | The TNM pN stage based on the number of metastatic lymph nodes is an independent prognostic factor in gastric cancer. Many studies have highlighted the phenomenon of stage migration and problems in comparing groups of patients with different numbers of total lymph nodes harvested within TNM staging. The current version of UICC/AJCC and JGCA TNM classifications postulates a minimal number of 16 lymph nodes as the base for N stage determination. Alternative systems such as lymph node ratio (LNR), positive to negative lymph node ratio (PNLNR), and LOGODDS (or LODDS), were implemented to increase the quality of LN assessment. These methods have reached the background in the literature, but to date no standard approach according to the cut-offs for the stages has been implemented. LOGODDS is the method that most reflects the number of harvested lymph nodes. The rationale for alternative staging methods, their correlations, and limitations are presented. |
Databáze: | OpenAIRE |
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