Physical therapy exerts sub-additive and suppressive effects on intracerebral neural stem cell implantation in a rat model of stroke
| Autor: | Alexander John Poplawsky, Lauren Grice, Franziska Nitzsche, Harmanvir Ghuman, Nikhita Perry, Jeffrey Moorhead, Michel Modo, Fabrisia Ambrosio, Madeline Gerwig |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Cell- and Tissue-Based Therapy Cell Line Cell therapy Grip strength Neural Stem Cells medicine Animals Humans Aerobic exercise Stroke Physical Therapy Modalities Neurorehabilitation business.industry Therapeutic effect Original Articles medicine.disease Neural stem cell Rats Clinical trial Neurology Physical therapy Neurology (clinical) Cardiology and Cardiovascular Medicine business Stem Cell Transplantation |
| Zdroj: | J Cereb Blood Flow Metab |
| ISSN: | 1559-7016 0271-678X |
| Popis: | Intracerebral cell therapy (CT) is emerging as a new therapeutic paradigm for stroke. However, the impact of physical therapy (PT) on implanted cells and their ability to promote recovery remains poorly understood. To address this translational issue, a clinical-grade neural stem cell (NSC) line was implanted into peri-infarct tissue using MRI-defined injection sites, two weeks after stroke. PT in the form of aerobic exercise (AE) was administered 5 × per week post-implantation using a paradigm commonly applied in patients with stroke. A combined AE and CT exerted sub-additive therapeutic effects on sensory neglect, whereas AE suppressed CT effects on motor integration and grip strength. Behavioral testing emerged as a potentially major component for task integration. It is expected that this study will guide and inform the incorporation of PT in the design of clinical trials evaluating intraparenchymal NSCs implantation for stroke. |
| Databáze: | OpenAIRE |
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