Maternal vitamin D intake during pregnancy and early childhood wheezing
| Autor: | Sheelagh Martindale, Leone C A Craig, Geraldine McNeill, Augusto A. Litonjua, Graham Devereux, Stephen W Turner, Anthony Seaton, Scott T. Weiss, Peter J. Helms |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Spirometry
medicine.medical_specialty Medicine (miscellaneous) Pregnancy Wheeze Internal medicine Surveys and Questionnaires medicine Vitamin D and neurology Humans Risk factor Vitamin D Asthma Respiratory Sounds Nutrition and Dietetics medicine.diagnostic_test business.industry Obstetrics medicine.disease Diet Endocrinology Child Preschool Exhaled nitric oxide Gestation Female medicine.symptom business |
| Zdroj: | The American journal of clinical nutrition. 85(3) |
| ISSN: | 0002-9165 |
| Popis: | Background: Maternal intake of vitamin D in pregnancy is a potentially modifiable but understudied risk factor for the development of asthma in children. Objective: We investigated whether maternal vitamin D intake in pregnancy is associated with decreased risks of wheezing symptoms in young children. Design: Subjects were from a birth cohort recruited in utero with the primary objective of identifying associations between maternal diet during pregnancy and asthma and allergies in children. A random sample of 2000 healthy pregnant women was recruited while attending antenatal clinics at the Aberdeen Maternity Hospital, Scotland, at 12 wk gestation. Maternal vitamin D intake was ascertained from a food-frequency questionnaire completed at 32 wk of gestation. The main outcome measures were wheezing symptoms, spirometry, bronchodilator response, atopic sensitization, and exhaled nitric oxide at 5 y. Results: Respiratory details through 5 y and maternal foodfrequency-questionnaire data were available for 1212 children. In models adjusted for potential confounders, including the children’s vitamin D intake, a comparison of the highest and lowest quintiles of maternal total vitamin D intake conferred lower risks for ever wheeze [odds ratio (OR): 0.48; 95% CI: 0.25, 0.91], wheeze in the previous year (OR: 0.35; 95% CI: 0.15, 0.83), and persistent wheeze (OR: 0.33; 95% CI: 0.11, 0.98) in 5-y-old children. In addition, lower maternal total vitamin D intakes in pregnancy were also associated with decreased bronchodilator response (P 0.04). No associations were observed between maternal vitamin D intakes and spirometry or exhaled nitric oxide concentrations. Conclusion: Increasing maternal vitamin D intakes during pregnancy may decrease the risk of wheeze symptoms in early childhood. Am J Clin Nutr 2007;85:853–9. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|