Prognostic significance of ACP5 expression in patients with lung adenocarcinoma
| Autor: | Yu-Jin Dong, Mei-Rong Liu, Ya-Li Gao, Shu-Xiang Yang, Xiao-Feng Tan |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine Oncology Adult Male medicine.medical_specialty Lung Neoplasms Blotting Western Adenocarcinoma of Lung Adenocarcinoma 03 medical and health sciences 0302 clinical medicine Osteoclast Internal medicine Immunology and Allergy Medicine Humans Lymph node Genetics (clinical) Survival analysis Aged Neoplasm Staging Retrospective Studies Aged 80 and over Lung business.industry Tartrate-Resistant Acid Phosphatase DNA Neoplasm Middle Aged medicine.disease Prognosis Immunohistochemistry Up-Regulation Gene Expression Regulation Neoplastic 030104 developmental biology medicine.anatomical_structure Tumor progression 030220 oncology & carcinogenesis Biomarker (medicine) Female business |
| Zdroj: | The clinical respiratory journal. 12(3) |
| ISSN: | 1752-699X |
| Popis: | Introduction Tartrate-resistant acid phosphatase 5 (ACP5), which is essential for bone resorption and osteoclast differentiation, promotes cell motility through the modulation of focal adhesion kinase phosphorylation. This study seeks to elucidate the association of ACP5 expression and the clinicopathologic characteristics of patients with lung adenocarcinoma (AD). Methods The expression of ACP5 was measured by Immunohistochemistry and Western blot analysis in lung AD and matched tumor-adjacent tissues, and the χ2 test was applied to analyze the correlation between ACP5 expression and clinicopathologic features. Using the Kaplan-Meier method, univariate and multivariate regression analysis was to explore the correlation between ACP5 expression and overall survival (OS). Results We found that ACP5 was frequently upregulated in lung AD tissues. The high expression of ACP5 was significantly related to lymph node status, tumor-node-metastasis (TNM) stage, and differentiation. From the results of univariate survival analysis, it indicated that the patients with high expression of ACP5 expression had a significantly lower OS than the patients with low expression of ACP5 expression. As it showed in Multivariate Cox regression analysis, the high expression of ACP5 expression was an independent prognostic factor for OS. Conclusions Our results suggest that high expression of ACP5 correlates with tumor progression and may serve as a potential prognostic biomarker in lung AD. |
| Databáze: | OpenAIRE |
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