Co‐Crystallization of Half‐Sandwich ( R M , R C )/( S M , R C ) Diastereomers in Single Crystals
| Autor: | Henri Brunner, Takashi Tsuno, Michael Bodensteiner, Stefanie Gärtner, Chiemi Miyahara, Seera Ito, Takaki Kurosawa, Kazuhiro Koyama |
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| Rok vydání: | 2016 |
| Předmět: |
Chemistry
Stereochemistry Dimer Diastereomer 010402 general chemistry 010403 inorganic & nuclear chemistry 01 natural sciences 0104 chemical sciences law.invention Inorganic Chemistry Metal chemistry.chemical_compound law visual_art X-ray crystallography visual_art.visual_art_medium Enantiomer Crystallization |
| Zdroj: | European Journal of Inorganic Chemistry. 2016:5405-5410 |
| ISSN: | 1099-0682 1434-1948 |
| DOI: | 10.1002/ejic.201600962 |
| Popis: | Diastereomer separation by fractional crystallization is the most important method for the resolution of enantiomers in research as well as in industry. Herein we describe two different types of diastereomer co-crystallization, which impede diastereomer separation. - The two diastereomers (RFe,RC)- and (SFe,RC)-[CpFe(Prophos)PPh(OMe)2]PF6, differing only in the metal configuration, form 1:1 co-crystals with a racemate-like lattice. Between the (RFe,RC)- and (SFe,RC)-diastereomers there is an almost-inversion center and the (RFe,RC)/(SFe,RC)-pair repeats as a kind of 'dimer' in the lattice. - Crystallization of a 50:50 diastereomer mixture of (RRu,RC)- and (SRu,RC)-[MeCpRu(Prophos)Cl] gave (RRu,RC)/(SRu,RC) 7:93 co-crystals and another crystallization diastereomerically pure (SRu,RC)-[MeCpRu(Prophos)Cl]. In the co-crystal the 93% component (SRu,RC)-[MeCpRu(Prophos)Cl] dictates the build-up of a conglomerate-like lattice and the 7% component (RRu,RC)-[MeCpRu(Prophos)Cl] has to adopt its M-Prophos chelate ring conformation, although diastereomerically pure (RRu,RC)-[MeCpRu(Prophos)Cl] has a completely different chelate ring conformation. |
| Databáze: | OpenAIRE |
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