Asymmetric synthesis of (2R,5R)-2,5-diaminohexan-1,6-dioic acid
| Autor: | Steven D. Bull, Stephen G. Davies, Richard M. Parkin, William O. Moss, Alexander N. Chernega |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Popis: | Schollkopf's auxiliary 16 was added to bis-lactim iodide 21 to give 1,2-bis[(3S,6R)-3,6-dihydro-2,5-dimethoxy-3-isopropylpyrazin-6-yl]ethane22 in 50% d.e. Dimer 22 was separated from its diastereoisomer 23 and deprotected using 6M HCl to afford homochiral (2R,5R)-2,5-diaminohexan-1,6-dioic acid 24. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|