Resective reoperation for failed epilepsy surgery: seizure outcome in 64 patients
| Autor: | Bernd W. Scheithauer, W. R. Marsh, Robyn L. McClelland, F. B. Meyer, A. M. Siegel, F. W. Sharbrough, G. D. Cascino, Elson L. So |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Reoperation medicine.medical_specialty Time Factors Adolescent Logistic regression Central nervous system disease Epilepsy Hematoma Postoperative Complications Recurrence Risk Factors Tuberous Sclerosis medicine Humans Ictal Epilepsy surgery Gliosis Age of Onset Child Retrospective Studies Tomography Emission-Computed Single-Photon business.industry Brain Neoplasms Infant Newborn Brain Infant Electroencephalography Odds ratio Middle Aged Clinical Science medicine.disease Magnetic Resonance Imaging Surgery Hemiparesis Treatment Outcome Anesthesia Child Preschool Female Neurology (clinical) Epilepsies Partial medicine.symptom business Tomography X-Ray Computed Follow-Up Studies |
| Zdroj: | Neurology. 63(12) |
| ISSN: | 1526-632X |
| Popis: | Objective: To determine the surgical outcome and factors of predictive value in patients undergoing reoperation for intractable partial epilepsy.Methods: The authors retrospectively studied the operative outcome in 64 consecutive patients who underwent reoperation for intractable partial epilepsy. Demographic data, results of comprehensive preoperative evaluations, and the seizure and neurologic outcome after reoperation were determined. All patients were followed a minimum of 1 year subsequent to their last operative procedure.Results: Fifty-three patients had two surgeries, and 11 patients had three or more operations. The first surgery involved a lesionectomy (n = 33), “nonlesional” temporal lobe resection (n = 28), and a “nonlesional” extratemporal resection (n = 3). The mean duration between the first and second procedure was 5.5 years. Fifty-five patients underwent an intralobar reoperation, whereas nine had a resection of a different lobe. After reoperation, 25 patients (39%) were free of seizure, 6 patients (9%) had rare seizures, 12 patients (19%) had a worthwhile improvement, and 21 patients (33%) failed to respond to surgery. Predictors of seizure-free outcome were age at seizure onset >15 years (p = 0.01), duration of epilepsy ≤5 years at the time of initial surgery (p = 0.03), and focal interictal discharges in scalp EEG (p = 0.03). Using a logistic regression model, two significant predictors emerged: duration of epilepsy ≤5 years (odds ratio, 3.18; p = 0.04) and preoperative focal interictal discharge (odds ratio, 4.45; p = 0.02). Complications of reoperation included visual field deficits (n = 9), wound infection (n = 2), subdural hematoma (n = 1), and hemiparesis (n = 1).Conclusion: Reoperation may be an appropriate alternative form of treatment for selected patients with intractable partial epilepsy who fail to respond to initial surgery. |
| Databáze: | OpenAIRE |
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