Effect of oral administration of Lactobacillus plantarum HY7714 on epidermal hydration in ultraviolet B-irradiated hairless mice
| Autor: | Sung Hwan Kim, Young-Tae Ahn, Sim Jae Hun, Hyung Keun Ku, Ji Woong Jeong, Dong Eun Lee, Woonhee Jeung, Il Dong Choi, Tae Youl Kim, Jehyeon Ra |
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| Rok vydání: | 2014 |
| Předmět: |
Ceramide
Ultraviolet Rays Photoaging Serine C-Palmitoyltransferase Administration Oral Applied Microbiology and Biotechnology Microbiology Cell Line chemistry.chemical_compound Oral administration In vivo Skin Physiological Phenomena medicine Ceramidases Animals Humans RNA Messenger Skin Transepidermal water loss Mice Hairless integumentary system biology Gene Expression Profiling Probiotics food and beverages General Medicine Fibroblasts Ceramidase medicine.disease biology.organism_classification Molecular biology Hairless chemistry bacteria Lactobacillus plantarum Biotechnology |
| Zdroj: | Journal of microbiology and biotechnology. 24(12) |
| ISSN: | 1738-8872 |
| Popis: | In this study, we evaluated the effect of Lactobacillus plantarum HY7714 on skin hydration in human dermal fibroblasts and in hairless mice. In Hs68 cells, L. plantarum HY7714 not only increased the serine palmitoyltransferase (SPT) mRNA level, but also decreased the ceramidase mRNA level. In order to confirm the hydrating effects of L. plantarum HY7714 in vivo, we orally administered vehicle or L. plantarum HY7714 at a dose of 1 × 10(9) CFU/day to hairless mice for 8 weeks. In hairless mice, L. plantarum HY7714 decreased UVB-induced epidermal thickness. In addition, we found that L. plantarum HY7714 administration suppressed the increase in transepidermal water loss and decrease in skin hydration, which reflects barrier function fluctuations following UV irradiation. In particular, L. plantarum HY7714 administration increased the ceramide level compared with that in the UVB group. In the experiment on SPT and ceramidase mRNA expressions, L. plantarum HY7714 administration improved the reduction in SPT mRNA levels and suppressed the increase in ceramidase mRNA levels caused by UVB in the hairless mice skins. Collectively, these results suggest that L. plantarum HY7714 can be a potential candidate for preserving skin hydration levels against UV irradiation. |
| Databáze: | OpenAIRE |
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