Selina-1,3,7(11)-trien-8-one and Oxidoselina-1,3,7(11)-trien-8-one from Eugenia uniflora Leaf Essential Oil and Their Cytotoxic Effects on Human Cell Lines

Autor: Luciana Azevedo, Jânio Sousa Santos, Cássia Gonçalves Magalhães, Vinicius Monteiro Schaffka, Marcos Felipe Maciel Pereira, Dilamara Riva Scharf, Jociani Ascari, Domingos Sávio Nunes, Daniel Granato, Marcos Vinicio Lopes Rodrigues Archilha, Mariana Araújo Vieira do Carmo
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Antioxidant
food.ingredient
Cell Survival
DPPH
medicine.medical_treatment
Pharmaceutical Science
Antineoplastic Agents
Naphthalenes
oxidoselina-1
3
7(11)-trien-8-one
Eugenia uniflora
Eugenia
01 natural sciences
Article
Antioxidants
Analytical Chemistry
law.invention
Lipid peroxidation
lcsh:QD241-441
chemistry.chemical_compound
0404 agricultural biotechnology
food
lcsh:Organic chemistry
law
Cell Line
Tumor
Drug Discovery
Oils
Volatile
medicine
Humans
Cytotoxic T cell
Physical and Theoretical Chemistry
selina-1
3
7(11)-trien-8-one
Cytotoxicity
Essential oil
010401 analytical chemistry
Organic Chemistry
04 agricultural and veterinary sciences
040401 food science
0104 chemical sciences
Plant Leaves
Biochemistry
chemistry
Chemistry (miscellaneous)
Cell culture
Molecular Medicine
cytotoxicity
Sesquiterpenes
Zdroj: Molecules, Vol 26, Iss 740, p 740 (2021)
Molecules
Volume 26
Issue 3
ISSN: 1420-3049
Popis: The sesquiterpenes selina-1,3,7(11)-trien-8-one and oxidoselina-1,3,7(11)-trien-8-one were isolated from the essential oil of Eugenia uniflora L. leaves. The structures were elucidated using spectrometric methods (UV, GC&ndash
MS, NMR, and specific optical rotation). The relationship between antioxidant activity, as determined by DPPH assay, and the cytotoxic effect was evaluated using tumor cells, namely lung adenocarcinoma epithelial cells (A549) and human hepatoma carcinoma cells (HepG2), as well as a model of normal human lung fibroblast cells (IMR90). Both compounds did not show prominent free-radical scavenging activity according to DPPH assay, and did not inhibit lipid peroxidation in Wistar rat brain homogenate. The isolated compounds showed pro-oxidative effects and cytotoxicity in relation to the IMR90 cell line.
Databáze: OpenAIRE
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