EFFECT OF CORTISONE ON SENSITIZED RH-NEGATIVE PREGNANT WOMEN AND AN ERYTHROBLASTOTIC INFANT

Autor: Frederic D. Regan, Waldo B. Edwards, Joseph F. Shanaphy, Alexander A. Doerner, Charles F. Naegele
Rok vydání: 1951
Předmět:
Zdroj: Journal of the American Medical Association. 147:1099
ISSN: 0002-9955
DOI: 10.1001/jama.1951.03670290007003
Popis: The discovery by Landsteiner and Wiener1in 1940 of the existence in man of a new blood factor, designated as Rh, and the later work of Levine and others,2who stressed the importance of this antigenic substance in the development of erythroblastosis fetalis, have initiated attempts by many investigators to discover methods of treating or preventing this hemolytic syndrome of the newborn. To date there have been no means described by which maternal immunization may be abolished or the degree of immunization lessened after the immune state has once been established. Although the treatment of the erythroblastotic infant has improved considerably, it still leaves much to be desired. Recent reports in the literature3and personal experience have indicated that adrenal steroids seem capable of intervening in the manifestations of hypersensitivity of body cells to bacterial and nonbacterial substances. We were interested to note the striking hematologic improvement
Databáze: OpenAIRE