The association of neutrophil-lymphocyte ratio and lymphocyte-monocyte ratio with 3-month clinical outcome after mechanical thrombectomy following stroke
| Autor: | Vafa Alakbarzade, Liqun Zhang, Luke Bridge, Camilla N. Clark, Brian Clarke, Danielle Lux, Anthony C Pereira, Usman Khan |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Neurology Neutrophils Lymphocyte Immunology Malignancy Logistic regression Monocytes lcsh:RC346-429 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Modified Rankin Scale Internal medicine medicine Humans Lymphocyte Count Lymphocytes Prospective Studies Stroke lcsh:Neurology. Diseases of the nervous system Aged Retrospective Studies Thrombectomy Neutrophil-lymphocyte ratio Aged 80 and over Receiver operating characteristic business.industry Research General Neuroscience Monocyte Lymphocyte-monocyte ratio Middle Aged medicine.disease Treatment Outcome 030104 developmental biology medicine.anatomical_structure Cardiology Female business Mechanical thrombectomy 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-9 (2020) Journal of Neuroinflammation |
| ISSN: | 1742-2094 |
| DOI: | 10.1186/s12974-020-01739-y |
| Popis: | Background and aim Neutrophil-lymphocyte ratio (NLR) and lymphocyte-monocyte ratio (LMR) are associated with clinical outcomes in malignancy, cardiovascular disease and stroke. Here we investigate their association with outcome after acute ischaemic stroke treated by mechanical thrombectomy (MT). Methods Patients were selected using audit data for MT for acute anterior circulation ischaemic stroke at a UK centre from May 2016–July 2017. Clinical and laboratory data including neutrophil, lymphocyte and monocyte count tested before and 24 h after MT were collected. Poor functional outcome was defined as modified Rankin Scale (mRS) of 3–6 at 3 months. Multivariable logistic regression analyses were performed to explore the relationship of NLR and LMR with functional outcome. Results One hundred twenty-one patients (mean age 66.4 ± 16.7, 52% female) were included. Higher NLR (adjusted OR 0.022, 95% CI, 0.009–0.34, p = 0.001) and lower LMR (adjusted OR − 0.093, 95% CI (− 0.175)−(− 0.012), p = 0.025) at 24-h post-MT were significantly associated with poorer functional outcome when controlling for age, baseline NIHSS score, infarct size, presence of good collateral supply, recanalisation and symptomatic intracranial haemorrhage on multivariate logistic regression. Admission NLR or LMR were not significant predictors of mRS at 3 months. The optimal cut-off values of NLR and LMR at 24-h post-MT that best discriminated poor outcome were 5.5 (80% sensitivity and 60% specificity) and 2.0 (80% sensitivity and 50% specificity), respectively on receiver operating characteristic curve analysis. Conclusion NLR and LMR tested at 24 h after ictus or intervention may predict 3-month functional outcome. |
| Databáze: | OpenAIRE |
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