Mast Cell Infiltration Is Associated With Persistent Symptoms and Endoscopic Abnormalities Despite Resolution of Eosinophilia in Pediatric Eosinophilic Esophagitis

Autor:	Ming Yu Wang, Paul J. Bryce, Hector Melin-Aldana, Katie Amsden, Joshua B. Wechsler, Scott M. Bolton, Evan S. Dellon, Amir F. Kagalwalla, Nicoleta C. Arva, Barry K. Wershil
Rok vydání:	2020
Předmět:	Male medicine.medical_specialty Adolescent Diet therapy Tryptase Gastroenterology Article 03 medical and health sciences 0302 clinical medicine Adrenal Cortex Hormones Edema Internal medicine medicine Humans Eosinophilia Mast Cells Esophagus Child Eosinophilic esophagitis Hepatology biology business.industry Eosinophilic Esophagitis Exudates and Transudates Eosinophil Hyperplasia medicine.disease Eosinophils medicine.anatomical_structure Child Preschool 030220 oncology & carcinogenesis biology.protein Female 030211 gastroenterology & hepatology Esophagoscopy medicine.symptom business Diet Therapy
Zdroj:	Am J Gastroenterol
ISSN:	1572-0241 0002-9270
Popis:	OBJECTIVES: Mast cells (MCs) are increased in eosinophilic esophagitis (EoE). Endoscopic abnormalities, symptoms, and epithelial changes can persist after treatment despite a reduction of esophageal eosinophilia. It is unknown whether this could be due to persistent MC infiltration. We aimed to determine whether patients with histologically inactive (HI) EoE (defined as
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cccb77ad69fedee898b7a6db26656e5 https://doi.org/10.14309/ajg.0000000000000474 Zobrazit plný text záznamu