Surrogate markers for survival in patients with AIDS and AIDS related complex treated with zidovudine
| Autor: | D. Mildvan, Judith C. Wilber, G. T. Valainis, Donald I. Abrams, S. Szabo, B. Polsky, A. Kolokathis, Mark A. Jacobson, Richard E. Chaisson, Peter Bacchetti |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male CD4-Positive T-Lymphocytes medicine.medical_specialty HIV Antigens Lymphocyte HIV Core Protein p24 AIDS-related complex Gene Products gag HIV Antibodies Neopterin Gastroenterology chemistry.chemical_compound Zidovudine Leukocyte Count Acquired immunodeficiency syndrome (AIDS) AIDS-Related Complex Predictive Value of Tests Internal medicine medicine Humans Retrospective Studies General Environmental Science Acquired Immunodeficiency Syndrome business.industry Proportional hazards model Beta-2 microglobulin Viral Core Proteins General Engineering General Medicine Middle Aged medicine.disease Prognosis Biopterin medicine.anatomical_structure chemistry HIV p24 Antigen Immunology CD4 Antigens General Earth and Planetary Sciences Female beta 2-Microglobulin business Biomarkers medicine.drug Research Article |
| Popis: | OBJECTIVE--To determine whether early effects of zidovudine treatment on CD4+ lymphocyte count and concentrations of beta 2 microglobulin, neopterin, or HIV p24 antigen or antibody are correlated with survival in patients with AIDS or AIDS related complex. DESIGN--Retrospective study of changes in laboratory markers and survival. SETTING--Multicentre trial at university hospital clinics. SUBJECTS--90 Patients with AIDS or AIDS related complex. INTERVENTION--Patients started zidovudine 200 mg orally every four hours. Fifty six of the patients died a median 17 months after starting zidovudine; the remaining 34 patients were followed up for a median 25.5 months. MAIN OUTCOME MEASURES--Changes in CD4+ lymphocyte count and serum concentrations of p24 antigen and antibody, beta 2 microglobulin, and neopterin; survival of the patient. RESULTS--The pretreatment characteristics that independently predicted poor survival were determined using a multivariate proportional hazards model: a diagnosis of AIDS (v AIDS related complex), age over 45 years, and the logarithm of serum neopterin concentration. When these baseline characteristics were controlled for the logarithm of CD4+ lymphocyte count at weeks 8-12 of treatment (p = 0.007) and an increase in serum beta 2 microglobulin concentration at weeks 8-12 (p = 0.05) also independently correlated with survival. In the 38 patients with a better pretreatment prognosis, 24 month survival estimated by the product-limit method was 88% for those with a good response on both surrogate markers during early treatment compared with only 50% for those with a poor response on either marker. In the 38 with a worse pretreatment prognosis, 24 month survival was estimated to be 49% for those with a good response on both surrogate markers compared with only 18% for those with a poor response on either. CONCLUSION--These data suggest that CD4+ lymphocyte count at 8-12 weeks and, perhaps, change in serum beta 2 microglobulin concentration could be surrogate end points for clinical outcome in trials of antiretroviral drugs for patients with HIV disease. |
| Databáze: | OpenAIRE |
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