Caveolae and Caveolins in the Respiratory System
| Autor: | Andrew J. Halayko, Reinoud Gosens, Sophie Bos, Sarah A. Martin, Sujata Basu, Mark M. Mutawe, Thai Tran |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Cell signaling
Pathology medicine.medical_specialty Lung Neoplasms Pulmonary Fibrosis Biology Caveolae Nitric Oxide Caveolins Biochemistry medicine Animals Humans RNA Messenger Cytoskeleton Receptor Molecular Biology Ion channel Lung Base Sequence General Medicine respiratory system Extracellular Matrix respiratory tract diseases Cell biology medicine.anatomical_structure Multigene Family Second messenger system Respiratory Physiological Phenomena Molecular Medicine Respiratory epithelium |
| Zdroj: | Current Molecular Medicine. 8:741-753 |
| ISSN: | 1566-5240 |
| DOI: | 10.2174/156652408786733720 |
| Popis: | Caveolae are flask-shaped invaginations of the plasma membrane that are present in most structu- ral cells. They owe their characteristic �-shape to complexes of unique proteins, the caveolins, which indirectly tether cholesterol and sphingolipid-enriched membrane microdomains to the cytoskeleton. Caveolins possess a unique scaffolding domain that anchors receptors, ion channels, second messenger producing enzymes, and effector kinases, thereby sequestering them to caveolae, and modulating cellular signaling and vesicular trans- port. The lungs express numerous caveolae and high levels of caveolins; therefore they likely play an impor- tant role in lung physiology. Indeed, recent and ongoing studies indicate important roles for caveolae and ca- veolins in the airway epithelium, airway smooth muscle, airway fibroblasts, airway inflammatory cells and the pulmonary vasculature. We review the role of caveolae and caveolins in lung cells and discuss their involve- ment in cellular signaling associated with asthma, COPD, lung cancer, idiopathic pulmonary fibrosis and pul- monary vascular defects. |
| Databáze: | OpenAIRE |
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