Discrepant expressive language lateralization in children and adolescents with epilepsy

Autor: Alisa Pasichnik, Melissa Tsuboyama, Ali Jannati, Clemente Vega, Harper L. Kaye, Ugur Damar, Jeffrey Bolton, Scellig S. D. Stone, Joseph R. Madsen, Ralph O. Suarez, Alexander Rotenberg
Rok vydání: 2022
Předmět:
Zdroj: Annals of Clinical and Translational Neurology. 9:1459-1464
ISSN: 2328-9503
Popis: Neuronavigated transcranial magnetic stimulation (nTMS) has emerged as a presurgical language mapping tool distinct from the widely used functional magnetic resonance imaging (fMRI). We report fMRI and nTMS language-mapping results in 19 pediatric-epilepsy patients and compare those to definitive testing by electrical cortical stimulation, Wada test, and/or neuropsychological testing. Most discordant results occurred when fMRI found right-hemispheric language. In those cases, when nTMS showed left-hemispheric or bilateral language representation, left-hemispheric language was confirmed by definitive testing. Therefore, we propose nTMS should be considered for pediatric presurgical language-mapping when fMRI shows right-hemispheric language, with nTMS results superseding fMRI results in those scenarios.
Databáze: OpenAIRE