A cytochemical and ultrastructural study of acute myelomonocytic leukemia exhibiting the pseudo-Chediak-Higashi anomaly of leukemia and 'splinter-type' Auer rods
| Autor: | Claire M. Payne, Edward J. Harrow |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Acute promyelocytic leukemia
Male Pathology medicine.medical_specialty Cytoplasm Biology Cytoplasmic Granules Translocation Genetic Myelogenous chemistry.chemical_compound Bone Marrow hemic and lymphatic diseases medicine Humans Aged Acute leukemia Staining and Labeling Auer rod Histocytochemistry General Medicine medicine.disease Leukemia Leukemia Myeloid Acute Butyrate esterase chemistry Acute myelomonocytic leukemia Sudan Black B Chediak-Higashi Syndrome |
| Zdroj: | American journal of clinical pathology. 80(2) |
| ISSN: | 0002-9173 |
| Popis: | An unusual case of acute myelomonocytic leukemia (AMML) in an 81-year-old man is described. Ultrastructural examination revealed the presence of distinct Auer bodies, which commonly are found in acute promyelocytic leukemia (APL). The Auer bodies had a splinterlike appearance with a distinct tubular substructure. The morphologic appearance of the leukemic cells coupled with the results of cytochemical staining reactions (alpha-naphthyl AS-D chloroacetate esterase, alpha-naphthyl butyrate esterase, Sudan black B, and periodic acid-Schiff reaction) identified this leukemia as myelomonocytic in origin. APL-like Auer rods in AMML now can be included in the spectrum of morphologic forms commonly seen in myelogenous leukemia and lends support to the hypothesis of an aberrant stem cell. In addition to the APL-like Auer rods, the leukemic blasts contained giant pink-staining granules on Wright's stain, some of which had a tubular substructure similar to the Auer rods under the electron microscope. The presence of these megagranules is a morphologic aberration termed "the pseudo-Chediak-Higashi anomaly of acute leukemia," and now has been described for the first time in AMML at the ultrastructural level. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|