Long-term outcome of thyroid lobectomy for unilateral multifocal papillary carcinoma
| Autor: | Xiaolei Wang, Shaoyan Liu, Zong-Min Zhang, Hui Huang, Zhen-Gang Xu, Song Ni |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Adolescent medicine.medical_treatment surgical treatment Observational Study 030209 endocrinology & metabolism Thyroid Lobectomy Kaplan-Meier Estimate Disease-Free Survival Thyroid carcinoma 03 medical and health sciences Young Adult 0302 clinical medicine Risk Factors medicine Carcinoma Humans Thyroid Neoplasms Survival rate Aged Proportional Hazards Models Retrospective Studies Completion thyroidectomy business.industry Hazard ratio Thyroid Thyroidectomy General Medicine Middle Aged multifocality medicine.disease Prognosis Carcinoma Papillary Surgery medicine.anatomical_structure Treatment Outcome 030220 oncology & carcinogenesis Multivariate Analysis papillary thyroid carcinoma Female Neoplasm Recurrence Local business Follow-Up Studies Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 |
| Popis: | The National Comprehensive Cancer Network (NCCN) guidelines recommend completion thyroidectomy for patients with multifocal papillary thyroid carcinoma (PTC) diagnosed by paraffin pathology after lobectomy. However, studies for the influence of surgical range on prognosis of unilateral multifocal carcinoma are scarce. We analyzed the clinicopathological characteristics and long-term outcomes of patients with unilateral multifocal PTC to identify risk factors for recurrence and disease-related death. The clinical and pathological data of 123 cases with multifocal lesions in the unilateral thyroid lobe were retrospectively collected, including sex, age, stage, surgical range, histopathology characteristics, and follow-up data. The prognostic factors were analyzed by means of the Kaplan–Meier method. The recurrence in the contralateral residual thyroid was observed in 6 cases. The 10-year cumulative recurrence rate of the remnant thyroid was 7.0%. Extrathyroidal extension (ETE) was a significant prognostic factor, with χ2 equal to 4.043 and a P value of .044. One patient died from progression of pulmonary metastasis during the follow-up. The 10-year disease-specific survival rate was 96% and 14 cases experienced recurrences and underwent a second surgery (11.4%), and thus the 10-year recurrence-free survival rate was 83.2%. Multivariate analysis showed that the pathologic tumor (pT) stage was an independent prognostic factor for the recurrence-free survival rate (P |
| Databáze: | OpenAIRE |
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