Paradoxical Effect of Grape Pomace Extract on Cisplatin-Induced Acute Kidney Injury in Rats
Autor: | Andrei Otto Mitre, Vlad Morhan, Dana Muntean, Maria Neag, Carmen Stanca Melincovici, Emil Claudiu Botan, Anca Dana Buzoianu, Calin Mitre, Adrian Catinean |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
medicine.medical_treatment
Pharmaceutical Science cisplatin Pharmacology Resveratrol resveratrol Article Nephrotoxicity 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Saline 030304 developmental biology Cisplatin 0303 health sciences Kidney business.industry nephrotoxicity Acute kidney injury medicine.disease grape extract medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis Toxicity Urea business medicine.drug |
Zdroj: | Pharmaceutics Volume 11 Issue 12 |
ISSN: | 1999-4923 |
DOI: | 10.3390/pharmaceutics11120656 |
Popis: | Cisplatin is one of the most used drugs in the therapy of different types of cancer. However, its use is limited by nephrotoxicity. This study investigated the effects of a commercially available grape pomace extract (GE) from Vitis vinifera on cisplatin-induced kidney toxicity in rats. Sixty-four male Wistar albino rats were randomly divided into eight groups. Groups 1&ndash 3 were controls, receiving 0.9% saline and doses 1 and 2 of GE respectively. Cisplatin was given to groups 4&ndash 8. Two groups received pretreatment with GE, while another two groups received pre- and post-treatment with GE. Blood samples were collected and all animals sacrificed. Kidneys were harvested for histopathological analysis. GE significantly increased blood creatinine and urea levels, the severity of kidney histopathological damage, and mortality in all cisplatin groups, except for group 7 which received pre- and post-treatment with a low dose of GE. Renal toxicity was determined by mortality and severe histopathological renal lesions. Additionally, the serum total antioxidant capacity (TAC) was not significantly modified in the treated groups compared to the control. These results indicate that the GE did not have a protective effect on cisplatin-induced nephrotoxicity on the contrary, GE accentuated the toxic effect of cisplatin. |
Databáze: | OpenAIRE |
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