Paradoxical Effect of Grape Pomace Extract on Cisplatin-Induced Acute Kidney Injury in Rats

Autor: Andrei Otto Mitre, Vlad Morhan, Dana Muntean, Maria Neag, Carmen Stanca Melincovici, Emil Claudiu Botan, Anca Dana Buzoianu, Calin Mitre, Adrian Catinean
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Pharmaceutics
Volume 11
Issue 12
ISSN: 1999-4923
DOI: 10.3390/pharmaceutics11120656
Popis: Cisplatin is one of the most used drugs in the therapy of different types of cancer. However, its use is limited by nephrotoxicity. This study investigated the effects of a commercially available grape pomace extract (GE) from Vitis vinifera on cisplatin-induced kidney toxicity in rats. Sixty-four male Wistar albino rats were randomly divided into eight groups. Groups 1&ndash
3 were controls, receiving 0.9% saline and doses 1 and 2 of GE respectively. Cisplatin was given to groups 4&ndash
8. Two groups received pretreatment with GE, while another two groups received pre- and post-treatment with GE. Blood samples were collected and all animals sacrificed. Kidneys were harvested for histopathological analysis. GE significantly increased blood creatinine and urea levels, the severity of kidney histopathological damage, and mortality in all cisplatin groups, except for group 7 which received pre- and post-treatment with a low dose of GE. Renal toxicity was determined by mortality and severe histopathological renal lesions. Additionally, the serum total antioxidant capacity (TAC) was not significantly modified in the treated groups compared to the control. These results indicate that the GE did not have a protective effect on cisplatin-induced nephrotoxicity
on the contrary, GE accentuated the toxic effect of cisplatin.
Databáze: OpenAIRE
Nepřihlášeným uživatelům se plný text nezobrazuje