The evolution of Pseudomonas aeruginosa during antibiotic rotation in a medical intensive care unit: the RADAR-trial
| Autor: | B. Chmielewski, H.J van Loon, Jan Verhoef, C. Cartwright, Chr. van der Werken, A. C. Fluit, Dean T. Tsukayama |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Microbiology (medical)
medicine.drug_class Antibiotics medicine.disease_cause Drug Administration Schedule Microbiology law.invention Antibiotic resistance law Drug Resistance Bacterial medicine Humans Pseudomonas Infections Pharmacology (medical) Genotyping Antibacterial agent Cross Infection biology Pseudomonas aeruginosa Pseudomonas General Medicine biology.organism_classification Intensive care unit Anti-Bacterial Agents Intensive Care Units Infectious Diseases Bacteria |
| Zdroj: | International Journal of Antimicrobial Agents. 24:339-345 |
| ISSN: | 0924-8579 |
| DOI: | 10.1016/j.ijantimicag.2004.04.011 |
| Popis: | Bacterial spread between patients may contribute to the high prevalence of antibiotic-resistant pathogens within ICUs. The aim of this study was to evaluate the fate of Pseudomonas aeruginosa during the different antibiotic regimens. Susceptibility patterns and genotyping were performed to determine whether there was a predominant clone and to track the spread of resistant strains within the unit. Twenty-eight different ribotypes were found among 82 Pseudomonas isolates. Four ribotypes accounted for 42 (51%) isolates and were designated the ‘major clones' occurring throughout multiple cycles. The ribotypes with multiple occurrences were more resistant to antibiotics than ribotypes that appeared only once. The correlation of antibiotic use with antibiotic resistance and the finding of a large number of ribotypes suggested that de novo development of antibiotic resistance is a likely event in P. aeruginosa . In addition, ribotypes associated with antibiotic resistance appeared to have a survival advantage and can become frequent colonizers in the ICU. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect