Aging Biomarkers: From Functional Tests to Multi-Omics Approaches
| Autor: | Nataliya S. Vorobyeva, Ksenia S. Kudryashova, Anton Kulaga, Brian K. Kennedy, Ksenia Burka |
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| Rok vydání: | 2019 |
| Předmět: |
Senescence
0303 health sciences Aging business.industry Biological age 030302 biochemistry & molecular biology Computational Biology Computational biology Omics Biochemistry Genomic Instability 03 medical and health sciences Mutation Medicine Multi omics Animals Humans business Molecular Biology Biomarkers Cellular Senescence 030304 developmental biology |
| Zdroj: | Proteomics. 20(5-6) |
| ISSN: | 1615-9861 |
| Popis: | Aging results in various deleterious changes in the human body that may lead to loss of function and the manifestation of chronic diseases. While diseases can generally be reliably diagnosed, the aging process itself requires more sophisticated approaches to evaluate its progression. Numerous attempts have been made to establish biomarkers to quantify human aging at the cellular, tissue, and organismal level. Here, an up-to-date overview of biomarkers related to human aging with an emphasis on biomarkers that take into account different mechanisms of aging between individuals is provided. Classical discrete molecular and non-molecular biomarkers handpicked by researches on the base of their strong correlation with age, as well as emerging omics-based biomarkers, are discussed and potential future directions and developments in the field of aging assessment are outlined. |
| Databáze: | OpenAIRE |
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