Co-infection of Schistosoma mansoni/hepatitis C virus and their associated factors among adult individuals living in fishing villages, north-western Tanzania
| Autor: | Godfrey M. Kaatano, Humphrey D. Mazigo, Stella Kepha, Safari Kinung’hi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Hepatosplenomegaly Rural Health medicine.disease_cause Gastroenterology Tanzania 0302 clinical medicine Medical microbiology Risk Factors Prevalence S. mansoni education.field_of_study biology Coinfection Fishing village Hepatitis C Middle Aged 3. Good health Co-infection Infectious Diseases Female Schistosoma mansoni medicine.symptom Research Article Hepatomegaly Adult medicine.medical_specialty Adolescent Hepatitis C virus 030231 tropical medicine Population Context (language use) lcsh:Infectious and parasitic diseases 03 medical and health sciences Periportal fibrosis Internal medicine parasitic diseases medicine Animals Humans lcsh:RC109-216 education business.industry medicine.disease biology.organism_classification Schistosomiasis mansoni 030104 developmental biology Cross-Sectional Studies Immunology Splenomegaly Morbidity business |
| Zdroj: | BMC Infectious Diseases BMC Infectious Diseases, Vol 17, Iss 1, Pp 1-9 (2017) |
| ISSN: | 1471-2334 |
| Popis: | Background Schistosoma mansoni and Hepatitis C virus (HCV) are co-existence in sub-Saharan Africa and co-infection is common among humans population. The immunological responses characterized with Th2-immune responses for S. mansoni and Th1-immune responses for HCV are responsible for development hepatic morbidities in infected individuals. However, the co-occurrences of S. mansoni and HCV infection, their related ultrasound detectable morbidities and associated risk factors at community levels have not been examined in fishing communities, north-western Tanzania. In this context, the present study covers that gap. Methods A cross-sectional study was conducted among 1924 asymptomatic individuals aged 15–55 years in four fishing villages (Igombe, Igalagala, Sangabuye and Kayenze) of Northwestern Tanzania. A single stool sample was collected from each study participants and examined for S. mansoni eggs using Kato Katz technique. Hepatitis C surface antigen (HCVsAg) was determined from a finger prick blood sample using a rapid test. Results Overall, 51.8% (997/1924; 95%CI: 49.6–54.1) of the study participants were infected with S. mansoni and had a mean intensity of 223.7epg (95%; 202.4–247.1). Of the study participants, 90 (4.7%) were infected with hepatitis C virus (HCV). Overall, 2. 4% (47/1924) of the study participants were co-infected with S. mansoni and hepatitis C virus. Among the co-infected individuals, 42.6%, 70.2% and 19.1% had splenomegaly, hepatomegaly and periportal fibrosis (PPF). Factors associated with S. mansoni/HCV co-infection were being aged 26–35 years (aRR = 2.67, 95%CI: 1.03–6.93, P |
| Databáze: | OpenAIRE |
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