Smoking as the potential link between Kimmelstiel-Wilson lesion and non-diabetic nodular glomerulosclerosis in male patients - a single center retrospective study
| Autor: | Péter Degrell, GergÅ Attila Molnár, István Wittmann, Richárd Halmai, István András Szijártó, Viktória Mátyás, Tibor Kovács |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Pathology Renal function Single Center Gastroenterology Statistics Nonparametric Diabetic nephropathy Lesion Internal medicine Diabetes mellitus medicine Prevalence Humans Diabetic Nephropathies Retrospective Studies Analysis of Variance Hungary medicine.diagnostic_test business.industry Glomerulosclerosis Focal Segmental Smoking Retrospective cohort study General Medicine Middle Aged medicine.disease Diabetes Mellitus Type 2 Nephrology Case-Control Studies Renal biopsy medicine.symptom business Body mass index |
| Zdroj: | Clinical nephrology. 80(1) |
| ISSN: | 0301-0430 |
| Popis: | BACKGROUND The histological pattern of nodular glomerulosclerosis (NGS) can be found both in diabetic nephropathy (Kimmelstiel-Wilson (KW) lesion) and non-diabetic nodular glomerulosclerosis (non-diab NGS). Chronic smoking is considered to be a potential cause of non-diab NGS, but the prevalence of smokers in KW is unknown. METHODS In a retrospective analysis, native renal biopsy specimens (n = 644, 2001 - 2011) were evaluated and male patients' characteristics, including smoking habits, were assessed within three groups: diabetic patients with KW (n = 15), diabetic patients with other classes of diabetic nephropathy (non-KW; n = 46), and patients with non-diab NGS (n = 7). RESULTS The majority of patients in the KW and non-diab NGS groups (13/15 = 87%, 7/7 = 100%, respectively; p = 1.0 vs. KW) were smokers, unlike the non-KW group (16/46 = 35%; p = 0.001 vs. KW). Cigarette pack-years showed a similar pattern (KW: 15 (6 - 30), non-KW: 0 (0 - 21), non-diab NGS: 30 (16 - 33); p = 0.010 non-KW vs. KW, p = 0.008 non-KW vs. non-diab NGS). Other known factors responsible for the worsening of non-KW or the development of non-diab NGS did not differ in the groups (age, body mass index, duration of diabetes mellitus, HbA1c, prevalence of hypertension, duration of hypertension, serum cholesterol, triglyceride, estimated glomerular filtration rate, and renin-angiotensin-aldosteron system-blocker treatment). CONCLUSIONS We propose that chronic cigarette smoking could play a pivotal role in the development of KW lesions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|