| Autor: |
F. Van Stalle, G. Lambelin, R. Deperon, J. Lansen, R. Roncucci |
| Rok vydání: |
1979 |
| Předmět: |
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| Zdroj: |
Thrombosis and Haemostasis. |
| ISSN: |
2567-689X |
| DOI: |
10.1055/s-0039-1684411 |
| Popis: |
Previous investigations based on the measurement of platelet regeneration time (PRT) rather than platelet survival time (PST) have suggested that this parameter is significantly reduced in patients bearing vascular prosthetic material and in a number of patients with occlusive vascular disease (1). Since it is well-known that shortened PST can be normalized by antiplatelet drug’s, it seemed interesting to investigate whether the measurement of PRT could also detect this effect. Suloctidil (S), a new vasoactive agent, has been chosen for this study which was performed in parallel double-blind conditions vs placebo. 32 patient. (24 males and 8 females) with either prosthetic heart valves, aortoiliac grafts or occlusive arterial disease were investigated [mean PRT t/2 value before treatment for the S group (n=16), 2.8±0.1 days]. They were given S at a dose of 600 mg daily during 3 to 4 weeks. The results obtained indicate that S treatment significantly increases shortened PRT t/2 values (mean PRT t/2 value after S treatment : 3.8±0.2 ; p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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